ENSG00000139626


Homo sapiens

Features
Gene ID: ENSG00000139626
  
Biological name :ITGB7
  
Synonyms : integrin subunit beta 7 / ITGB7 / P26010
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 53191318
Gene end: 53207307
  
Corresponding Affymetrix probe sets: 205718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456446
Ensembl peptide - ENSP00000455374
Ensembl peptide - ENSP00000456305
Ensembl peptide - ENSP00000267082
Ensembl peptide - ENSP00000408741
Ensembl peptide - ENSP00000437375
Ensembl peptide - ENSP00000446703
Ensembl peptide - ENSP00000450366
NCBI entrez gene - 3695     See in Manteia.
OMIM - 147559
RefSeq - XM_006719376
RefSeq - NM_000889
RefSeq - XM_005268851
RefSeq - XM_005268852
RefSeq Peptide - NP_000880
swissprot - F5H6T4
swissprot - H3BRX4
swissprot - F8VNX4
swissprot - F8W186
swissprot - H3BRM2
swissprot - P26010
Ensembl - ENSG00000139626
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb7ENSDARG00000044318Danio rerio
 Itgb7ENSMUSG00000001281Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITGB2 / P05107 / integrin subunit beta 2ENSG0000016025546
ITGB1 / P05556 / integrin subunit beta 1ENSG0000015009342
ITGB5 / P18084 / integrin subunit beta 5ENSG0000008278137
ITGB3 / P05106 / integrin subunit beta 3ENSG0000025920737
AC068234.1ENSG0000025975337
ITGB6 / P18564 / integrin subunit beta 6ENSG0000011522136
ITGB4 / P16144 / integrin subunit beta 4ENSG0000013247031
ITGB8 / P26012 / integrin subunit beta 8ENSG0000010585528
ITGBL1 / O95965 / integrin subunit beta like 1ENSG0000019854215


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015437  Integrin beta-7 subunit
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003366 cell-matrix adhesion involved in ameboidal cell migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050901 leukocyte tethering or rolling IMP
 biological_processGO:0072678 T cell migration IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008305 integrin complex IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034669 integrin alpha4-beta7 complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IMP


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099866 Q13477 / MADCAM1 / mucosal vascular addressin cell adhesion molecule 1  / complex / reaction
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / complex
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction / complex
 ENSG00000083457 ITGAE / P38570 / integrin subunit alpha E  / complex






 

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