ENSG00000137801


Homo sapiens

Features
Gene ID: ENSG00000137801
  
Biological name :THBS1
  
Synonyms : P07996 / THBS1 / thrombospondin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q14
Gene start: 39581079
Gene end: 39599466
  
Corresponding Affymetrix probe sets: 201107_s_at (Human Genome U133 Plus 2.0 Array)   201108_s_at (Human Genome U133 Plus 2.0 Array)   201109_s_at (Human Genome U133 Plus 2.0 Array)   201110_s_at (Human Genome U133 Plus 2.0 Array)   215775_at (Human Genome U133 Plus 2.0 Array)   235086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260356
Ensembl peptide - ENSP00000380720
NCBI entrez gene - 7057     See in Manteia.
OMIM - 188060
RefSeq - NM_003246
RefSeq - XM_011521971
RefSeq Peptide - NP_003237
swissprot - A8MZG1
swissprot - P07996
Ensembl - ENSG00000137801
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs1bENSDARG00000010785Danio rerio
 THBS1ENSGALG00000009626Gallus gallus
 Thbs1ENSMUSG00000040152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THBS2 / P35442 / thrombospondin 2ENSG0000018634062
THBS4 / P35443 / thrombospondin 4ENSG0000011329634
THBS3 / P49746 / thrombospondin 3ENSG0000016923134
COMP / P49747 / cartilage oligomeric matrix proteinENSG0000010566431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR028499  Thrombospondin-1
 IPR028974  TSP type-3 repeat
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001666 response to hypoxia NAS
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IDA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002544 chronic inflammatory response IEP
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IDA
 biological_processGO:0002605 negative regulation of dendritic cell antigen processing and presentation IDA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006955 immune response IEP
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009749 response to glucose IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IDA
 biological_processGO:0010751 negative regulation of nitric oxide mediated signal transduction IDA
 biological_processGO:0010754 negative regulation of cGMP-mediated signaling IDA
 biological_processGO:0010757 negative regulation of plasminogen activation IDA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis ISS
 biological_processGO:0010763 positive regulation of fibroblast migration IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0030194 positive regulation of blood coagulation IDA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IDA
 biological_processGO:0032026 response to magnesium ion IDA
 biological_processGO:0032570 response to progesterone TAS
 biological_processGO:0032695 negative regulation of interleukin-12 production IDA
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production ISS
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034605 cellular response to heat NAS
 biological_processGO:0034976 response to endoplasmic reticulum stress ISS
 biological_processGO:0036066 protein O-linked fucosylation TAS
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IDA
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA
 biological_processGO:0043032 positive regulation of macrophage activation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043652 engulfment of apoptotic cell IDA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048266 behavioral response to pain ISS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0051895 negative regulation of focal adhesion assembly TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0051918 negative regulation of fibrinolysis IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IDA
 biological_processGO:2001027 negative regulation of endothelial cell chemotaxis IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005577 fibrinogen complex IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0031012 extracellular matrix TAS
 cellular_componentGO:0031091 platelet alpha granule IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0001968 fibronectin binding IDA
 molecular_functionGO:0005178 integrin binding IMP
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding NAS
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0017134 fibroblast growth factor binding IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0042802 identical protein binding NAS
 molecular_functionGO:0043236 laminin binding IDA
 molecular_functionGO:0043394 proteoglycan binding TAS
 molecular_functionGO:0050431 transforming growth factor beta binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA
 molecular_functionGO:0070051 fibrinogen binding IDA
 molecular_functionGO:0070052 collagen V binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005884 ITGA3 / P26006 / integrin subunit alpha 3  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex
 ENSG00000115232 ITGA4 / P13612 / integrin subunit alpha 4  / reaction / complex
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000137801 THBS1 / P07996 / thrombospondin 1  / complex
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction / complex






 

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