ENSG00000113296


Homo sapiens

Features
Gene ID: ENSG00000113296
  
Biological name :THBS4
  
Synonyms : P35443 / THBS4 / thrombospondin 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q14.1
Gene start: 79991311
Gene end: 80083287
  
Corresponding Affymetrix probe sets: 204776_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339730
Ensembl peptide - ENSP00000422298
NCBI entrez gene - 7060     See in Manteia.
OMIM - 600715
RefSeq - NM_003248
RefSeq - XM_017009800
RefSeq - NM_001306212
RefSeq - NM_001306213
RefSeq - NM_001306214
RefSeq - XM_017009798
RefSeq - XM_017009799
RefSeq Peptide - NP_001293143
RefSeq Peptide - NP_003239
RefSeq Peptide - NP_001293141
RefSeq Peptide - NP_001293142
swissprot - P35443
swissprot - E7ES19
Ensembl - ENSG00000113296
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs4aENSDARG00000102777Danio rerio
 thbs4bENSDARG00000020072Danio rerio
 THBS4ENSGALG00000014804Gallus gallus
 Thbs4ENSMUSG00000021702Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THBS3 / P49746 / thrombospondin 3ENSG0000016923161
COMP / P49747 / cartilage oligomeric matrix proteinENSG0000010566454
THBS1 / P07996 / thrombospondin 1ENSG0000013780142
THBS2 / P35442 / thrombospondin 2ENSG0000018634042


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024665  Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
 IPR028974  TSP type-3 repeat
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEP
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0034103 regulation of tissue remodeling IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051451 myoblast migration IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0071603 endothelial cell-cell adhesion IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IDA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr