ENSG00000186340


Homo sapiens

Features
Gene ID: ENSG00000186340
  
Biological name :THBS2
  
Synonyms : P35442 / THBS2 / thrombospondin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q27
Gene start: 169215780
Gene end: 169254044
  
Corresponding Affymetrix probe sets: 203083_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482784
Ensembl peptide - ENSP00000355751
Ensembl peptide - ENSP00000398928
NCBI entrez gene - 7058     See in Manteia.
OMIM - 188061
RefSeq - NM_003247
RefSeq Peptide - NP_003238
swissprot - P35442
swissprot - Q5RI53
Ensembl - ENSG00000186340
  
Related genetic diseases (OMIM): 603932 - {Lumbar disc herniation, susceptibility to}, 603932
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs2aENSDARG00000060410Danio rerio
 thbs2bENSDARG00000073810Danio rerio
 THBS2ENSGALG00000011200Gallus gallus
 Thbs2ENSMUSG00000023885Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THBS1 / P07996 / thrombospondin 1ENSG0000013780162
THBS4 / P35443 / thrombospondin 4ENSG0000011329634
THBS3 / P49746 / thrombospondin 3ENSG0000016923134
COMP / P49747 / cartilage oligomeric matrix proteinENSG0000010566432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015455  Thrombospondin-2
 IPR017897  Thrombospondin, type 3 repeat
 IPR024731  EGF domain
 IPR028974  TSP type-3 repeat
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031091 platelet alpha granule IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding TAS


Pathways (from Reactome)
Pathway description
Signaling by PDGF
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction






 

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