ENSMUSG00000021702


Mus musculus

Features
Gene ID: ENSMUSG00000021702
  
Biological name :Thbs4
  
Synonyms : Q9Z1T2 / Thbs4 / thrombospondin 4
  
Possible biological names infered from orthology : P35443
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 92751590
Gene end: 92794818
  
Corresponding Affymetrix probe sets: 10411082 (MoGene1.0st)   1449388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022213
NCBI entrez gene - 21828     See in Manteia.
MGI - MGI:1101779
RefSeq - NM_011582
RefSeq Peptide - NP_035712
swissprot - B2RTL6
swissprot - Q9Z1T2
Ensembl - ENSMUSG00000021702
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbs4aENSDARG00000102777Danio rerio
 thbs4bENSDARG00000020072Danio rerio
 THBS4ENSGALG00000014804Gallus gallus
 THBS4ENSG00000113296Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thbs3 / Q05895 / Thrombospondin-3 / P49746*ENSMUSG0000002804760
Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*ENSMUSG0000003184955
Thbs2 / Q03350 / Thrombospondin-2 / P35442*ENSMUSG0000002388542
Thbs1 / thrombospondin 1 / P07996*ENSMUSG0000004015241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024665  Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
 IPR028974  TSP type-3 repeat
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0034103 regulation of tissue remodeling IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0048266 behavioral response to pain IMP
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051451 myoblast migration ISO
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0071603 endothelial cell-cell adhesion ISO
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr1h4tm1Gonz/Nr1h4tm1Gonz
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex






 

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