ENSMUSG00000031849


Mus musculus

Features
Gene ID: ENSMUSG00000031849
  
Biological name :Comp
  
Synonyms : Cartilage oligomeric matrix protein / Comp / Q9R0G6
  
Possible biological names infered from orthology : P49747
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70373558
Gene end: 70382066
  
Corresponding Affymetrix probe sets: 10572378 (MoGene1.0st)   1419527_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003659
Ensembl peptide - ENSMUSP00000148712
Ensembl peptide - ENSMUSP00000148626
NCBI entrez gene - 12845     See in Manteia.
MGI - MGI:88469
RefSeq - NM_016685
RefSeq - XM_006509539
RefSeq Peptide - NP_057894
swissprot - A0A1D5RMB8
swissprot - Q9R0G6
swissprot - A0A1D5RM48
Ensembl - ENSMUSG00000031849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COMPENSDARG00000098431Danio rerio
 COMPENSGALG00000003283Gallus gallus
 COMPENSG00000105664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thbs4 / Q9Z1T2 / thrombospondin 4 / P35443*ENSMUSG0000002170270
Thbs3 / Q05895 / Thrombospondin-3 / P49746*ENSMUSG0000002804764
Thbs1 / thrombospondin 1 / P07996*ENSMUSG0000004015249
Thbs2 / Q03350 / Thrombospondin-2 / P35442*ENSMUSG0000002388549


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024665  Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
 IPR028492  Cartilage oligomeric matrix protein
 IPR028974  TSP type-3 repeat
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003417 growth plate cartilage development IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0060173 limb development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Comptm2.1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: C57BL/6J * C3H * NIH

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003098 reduced tendon stiffness "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Comptm2.1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smg6tm1.1Zqw/Smg6tm1.1Zqw,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Comptm2.1Mbri/Comptm2.1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Prkcitm1Kido/Prkcitm1Kido,Tg(Cryaa-cre)10Mlr/?
Genetic Background: involves: FVB/N

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Tg(Tyr-cre)2Lru/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Comptm1Mbri/Comp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031849 Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*  / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000055447 Cd47 / Q61735 / Leukocyte surface antigen CD47 / Q08722* / CD47 molecule*  / complex / reaction
 ENSMUSG00000000555 Itga5 / P11688 / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain / P08648* / integrin subunit alpha 5*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / reaction / complex
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / reaction / complex






 

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