ENSMUSG00000028047


Mus musculus

Features
Gene ID: ENSMUSG00000028047
  
Biological name :Thbs3
  
Synonyms : Q05895 / Thbs3 / Thrombospondin-3
  
Possible biological names infered from orthology : P49746
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 89215180
Gene end: 89226837
  
Corresponding Affymetrix probe sets: 10493449 (MoGene1.0st)   1416623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120337
Ensembl peptide - ENSMUSP00000029682
Ensembl peptide - ENSMUSP00000112912
Ensembl peptide - ENSMUSP00000116136
NCBI entrez gene - 21827     See in Manteia.
MGI - MGI:98739
RefSeq - XM_011240072
RefSeq - NM_013691
RefSeq - XM_006501295
RefSeq Peptide - NP_038719
swissprot - D3Z6N1
swissprot - Q05895
swissprot - F6W6J3
swissprot - E9PWF0
Ensembl - ENSMUSG00000028047
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1L8P7ENSDARG00000012060Danio rerio
 thbs3aENSDARG00000077641Danio rerio
 THBS3ENSG00000169231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Thbs4 / Q9Z1T2 / thrombospondin 4 / P35443*ENSMUSG0000002170260
Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*ENSMUSG0000003184950
Thbs2 / Q03350 / Thrombospondin-2 / P35442*ENSMUSG0000002388542
Thbs1 / thrombospondin 1 / P07996*ENSMUSG0000004015242


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003367  Thrombospondin, type 3-like repeat
 IPR008859  Thrombospondin, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017897  Thrombospondin, type 3 repeat
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024665  Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
 IPR028507  Thrombospondin-3
 IPR028974  TSP type-3 repeat
 IPR037349  Thrombospondin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003417 growth plate cartilage development IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0060346 bone trabecula formation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction / complex






 

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