ENSMUSG00000000489


Mus musculus

Features
Gene ID: ENSMUSG00000000489
  
Biological name :Pdgfb
  
Synonyms : Pdgfb / platelet derived growth factor, B polypeptide
  
Possible biological names infered from orthology : P01127 / platelet derived growth factor subunit B
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79995874
Gene end: 80014977
  
Corresponding Affymetrix probe sets: 10430660 (MoGene1.0st)   1450413_at (Mouse Genome 430 2.0 Array)   1450414_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155133
Ensembl peptide - ENSMUSP00000000500
Ensembl peptide - ENSMUSP00000154843
NCBI entrez gene - 18591     See in Manteia.
MGI - MGI:97528
RefSeq - NM_011057
RefSeq - XM_006520592
RefSeq - XM_017316502
RefSeq Peptide - NP_035187
swissprot - A0A0R4IZW4
Ensembl - ENSMUSG00000000489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfbaENSDARG00000086778Danio rerio
 pdgfbbENSDARG00000038139Danio rerio
 PDGFBENSGALG00000012178Gallus gallus
 PDGFBENSG00000100311Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdgfa / platelet derived growth factor subunit A / P04085*ENSMUSG0000002585636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR006782  Platelet-derived growth factor, N-terminal
 IPR015583  Platelet-derived growth factor subunit B
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010512 negative regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0010544 negative regulation of platelet activation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0035655 interleukin-18-mediated signaling pathway IEA
 biological_processGO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1905064 negative regulation of vascular smooth muscle cell differentiation IEA
 biological_processGO:1905176 positive regulation of vascular smooth muscle cell dedifferentiation IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000591 positive regulation of metanephric mesenchymal cell migration IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Fabp4-lacZ)4Mosh/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet,Tg(Fabp4-lacZ)4Mosh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006186 retinal fibrosis "invasion of fibrous connective tissue into the retina, often resulting from inflammation or injury" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010451 kidney microaneurysm "focal dilation of arteriocapillary junctions in the kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010479 brain aneurysm "a protruding sac within the brain formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011428 mesangial cell hypoplasia "decreased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011429 absent mesangial cell "absence of the phagocytic cells in the capillary tuft of the renal glomerulus, normally interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011509 dilated glomerular capillary "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020329 decreased capillary density "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sor+,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(PDGFB)Cbet/Gt(ROSA)26Sortm1(PDGFB)Cbet,Pdgfbtm1Cbet/Pdgfbtm1Cbet,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020331 increased capillary tortuosity "increase in the degree of twisting of capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMCID:PMC3369246]
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Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000021702 Thbs4 / Q9Z1T2 / thrombospondin 4 / P35443*  / reaction / complex
 ENSMUSG00000028047 Thbs3 / Q05895 / Thrombospondin-3 / P49746*  / complex / reaction
 ENSMUSG00000029304 Spp1 / P10923 / secreted phosphoprotein 1 / P10451*  / reaction / complex
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / complex / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000023885 Thbs2 / Q03350 / Thrombospondin-2 / P35442*  / complex / reaction






 

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