ENSMUSG00000031955


Mus musculus

Features
Gene ID: ENSMUSG00000031955
  
Biological name :Bcar1
  
Synonyms : Bcar1 / Breast cancer anti-estrogen resistance protein 1 / Q61140
  
Possible biological names infered from orthology : BCAR1, Cas family scaffolding protein / P56945
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 111710474
Gene end: 111743809
  
Corresponding Affymetrix probe sets: 10581890 (MoGene1.0st)   1439388_s_at (Mouse Genome 430 2.0 Array)   1450622_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129584
Ensembl peptide - ENSMUSP00000148364
NCBI entrez gene - 12927     See in Manteia.
MGI - MGI:108091
RefSeq - XM_011248299
RefSeq - NM_001198839
RefSeq - NM_009954
RefSeq Peptide - NP_034084
RefSeq Peptide - NP_001185768
swissprot - Q61140
Ensembl - ENSMUSG00000031955
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcar1ENSDARG00000056525Danio rerio
 BCAR1ENSGALG00000042895Gallus gallus
 BCAR1ENSG00000050820Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nedd9 / O35177 / neural precursor cell expressed, developmentally down-regulated gene 9 / Q14511* / neural precursor cell expressed, developmentally down-regulated 9*ENSMUSG0000002136539
Efs / Q64355 / Embryonal Fyn-associated substrate / O43281*ENSMUSG0000002220323
Cass4 / Q08EC4 / Cas scaffolding protein family member 4 / Q9NQ75*ENSMUSG0000007457022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR014928  Serine rich protein interaction domain
 IPR021901  CAS family, C-terminal
 IPR028848  Breast cancer anti-estrogen resistance protein 1
 IPR035745  BCAR1, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037362  CAS family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway ISS
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway ISO
 biological_processGO:0050851 antigen receptor-mediated signaling pathway ISO
 biological_processGO:0050853 B cell receptor signaling pathway ISS
 biological_processGO:0060326 cell chemotaxis ISO
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO


Pathways (from Reactome)
Pathway description
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction / complex
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / reaction / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction / complex
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction / complex
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / reaction / complex






 

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