ENSMUSG00000058325


Mus musculus

Features
Gene ID: ENSMUSG00000058325
  
Biological name :Dock1
  
Synonyms : Dedicator of cytokinesis protein 1 / Dock1 / Q8BUR4
  
Possible biological names infered from orthology : dedicator of cytokinesis 1 / Q14185
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 134670654
Gene end: 135173639
  
Corresponding Affymetrix probe sets: 10558345 (MoGene1.0st)   1443991_at (Mouse Genome 430 2.0 Array)   1452220_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081531
Ensembl peptide - ENSMUSP00000147945
Ensembl peptide - ENSMUSP00000147797
NCBI entrez gene - 330662     See in Manteia.
MGI - MGI:2429765
RefSeq - NM_001033420
RefSeq - XM_006507965
RefSeq Peptide - NP_001028592
swissprot - A0A1B0GSI1
swissprot - Q8BUR4
swissprot - A0A1B0GS53
Ensembl - ENSMUSG00000058325
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock1ENSDARG00000099093Danio rerio
 DOCK1ENSGALG00000042259Gallus gallus
 DOCK1ENSG00000150760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock5 / B2RY04 / Dedicator of cytokinesis protein 5 / Q9H7D0* / dedicator of cytokinesis 5*ENSMUSG0000004444765
Dock2 / Q8C3J5 / Dedicator of cytokinesis protein 2 / Q92608* / dedicator of cytokinesis 2*ENSMUSG0000002014358
Dock4 / P59764 / Dedicator of cytokinesis protein 4 / Q8N1I0* / dedicator of cytokinesis 4*ENSMUSG0000003595437
Dock3 / dedicator of cytokinesis 3 / Q8IZD9*ENSMUSG0000003971637


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR030717  Dedicator of cytokinesis protein 1
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035892  C2 domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration ISO
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

Allelic Composition: Dock1tm2.1Jfco/Dock1+,Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic Background: involves: C57BL/6 * FVB/NJ

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
Show

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

 MP:0006130 pulmonary valve atresia "congenital closure of the pulmonary valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah5b2b2925Clo/Dnah5b2b2925Clo
Genetic Background: C57BL/6J-Dnah5b2b2925Clo

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

Allelic Composition: Dock1tm1Jfco/Dock1+,Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

Allelic Composition: Dock1tm2.1Jfco/Dock1+,Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic Background: involves: C57BL/6 * FVB/NJ

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1tm1.1Arte/Hmx1tm1.1Arte,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: BALB/c * C57BL/6J * CBA/J

Allelic Composition: Dock1tm2.1Jfco/Dock1+,Tg(MMTV-Erbb2*,-cre)1Mul/0
Genetic Background: involves: C57BL/6 * FVB/NJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

Allelic Composition: Dock1b2b3190Clo/Dock1b2b3190Clo
Genetic Background: C57BL/6J-Dock1b2b3190Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
Show

Allelic Composition: Dock1b2b3190Clo/Dock1b2b3190Clo
Genetic Background: C57BL/6J-Dock1b2b3190Clo

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0010617 thick mitral valve cusps 
Show

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dock1tm1.1Ysfk/Dock1tm1.1Ysfk
Genetic Background: B6(Cg)-Dock1tm1.1Ysfk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction / complex
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex / reaction
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction / complex
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex






 

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