ENSMUSG00000020143


Mus musculus

Features
Gene ID: ENSMUSG00000020143
  
Biological name :Dock2
  
Synonyms : Dedicator of cytokinesis protein 2 / Dock2 / Q8C3J5
  
Possible biological names infered from orthology : dedicator of cytokinesis 2 / Q92608
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 34226815
Gene end: 34783892
  
Corresponding Affymetrix probe sets: 10385118 (MoGene1.0st)   1422808_s_at (Mouse Genome 430 2.0 Array)   1438334_at (Mouse Genome 430 2.0 Array)   1444741_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090884
Ensembl peptide - ENSMUSP00000098915
Ensembl peptide - ENSMUSP00000098916
Ensembl peptide - ENSMUSP00000116893
NCBI entrez gene - 94176     See in Manteia.
MGI - MGI:2149010
RefSeq - XM_017314862
RefSeq - NM_033374
RefSeq - XM_017314861
RefSeq Peptide - NP_203538
swissprot - Q3TMS1
swissprot - Q5SRI3
swissprot - Q8C3J5
swissprot - D6RGU3
Ensembl - ENSMUSG00000020143
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018106.1ENSDARG00000114649Danio rerio
 LO018106.2ENSDARG00000114803Danio rerio
 LO018564.1ENSDARG00000112944Danio rerio
 DOCK2ENSGALG00000002080Gallus gallus
 DOCK2ENSG00000134516Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*ENSMUSG0000005832559
Dock5 / B2RY04 / Dedicator of cytokinesis protein 5 / Q9H7D0* / dedicator of cytokinesis 5*ENSMUSG0000004444755
Dock4 / P59764 / Dedicator of cytokinesis protein 4 / Q8N1I0* / dedicator of cytokinesis 4*ENSMUSG0000003595436
Dock3 / dedicator of cytokinesis 3 / Q8IZD9*ENSMUSG0000003971636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR026799  Dedicator of cytokinesis protein 2
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001766 membrane raft polarization IMP
 biological_processGO:0001768 establishment of T cell polarity IMP
 biological_processGO:0001771 immunological synapse formation IMP
 biological_processGO:0002277 myeloid dendritic cell activation involved in immune response IMP
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0035022 positive regulation of Rac protein signal transduction IC
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044351 macropinocytosis IMP
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0046631 alpha-beta T cell activation IMP
 biological_processGO:0046633 alpha-beta T cell proliferation IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0042608 T cell receptor binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm1(EGFP/cre)Cjt/Shh+,Sox17tm1Ysk/Sox17+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dock2m7Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m7Btlr

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3(tetO-EGFP,-RNAi:T)Bgh/Gt(ROSA)26Sor
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * NMRI

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Qtrt1Gt(S12-11A1)Sor/Qtrt1+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: C57BL/6J-Dock2m2Btlr

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Qtrt1Gt(S12-11A1)Sor/Qtrt1+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Qtrt1Gt(S12-11A1)Sor/Qtrt1+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m4Btlr/Dock2m4Btlr
Genetic Background: C57BL/6J-Dock2m4Btlr

Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dock2m3Anu/Dock2m3Anu
Genetic Background: C57BL/6NCrlAnu-Dock2m3Anu

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rims1tm3.1Sud/Rims1tm3.1Sud
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Dock2m7Btlr/Dock2m7Btlr
Genetic Background: C57BL/6J-Dock2m7Btlr

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0002634 abnormal sensorimotor gating "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0002895 abnormal otolithic membrane "malformations of the gelatinous membrane surmounting the acoustic maculae of the saccule and utricle and containing minute calciferous particles (otoliths)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Btlr/Dock2m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dock2m3Anu/Dock2m3Anu
Genetic Background: C57BL/6NCrlAnu-Dock2m3Anu

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Qtrt1Gt(S12-11A1)Sor/Qtrt1+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: C57BL/6J-Dock2m2Btlr

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m1Anu/Dock2m1Anu
Genetic Background: C57BL/6JAnu-Dock2m1Anu

Allelic Composition: Dock2m7Btlr/Dock2m7Btlr
Genetic Background: C57BL/6J-Dock2m7Btlr

Allelic Composition: Dock2m7Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m7Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Dock2m1Btlr/Dock2m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Dock2m2Anu/Dock2m2Anu
Genetic Background: C57BL/6JAnu-Dock2m2Anu

Allelic Composition: Dock2m1Anu/Dock2m1Anu
Genetic Background: C57BL/6JAnu-Dock2m1Anu

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Dock2m7Btlr/Dock2m7Btlr
Genetic Background: C57BL/6J-Dock2m7Btlr

Allelic Composition: Dock2m7Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m7Btlr

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m2Anu/Dock2m2Anu
Genetic Background: C57BL/6JAnu-Dock2m2Anu

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Dock2m7Btlr/Dock2m7Btlr
Genetic Background: C57BL/6J-Dock2m7Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: C57BL/6J-Dock2m2Btlr

Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

Allelic Composition: Dock2m3Anu/Dock2m3Anu
Genetic Background: C57BL/6NCrlAnu-Dock2m3Anu

Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

Allelic Composition: Dock2m4Btlr/Dock2m4Btlr
Genetic Background: C57BL/6J-Dock2m4Btlr

Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m2Btlr/Dock2m2Btlr
Genetic Background: C57BL/6J-Dock2m2Btlr

Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

Allelic Composition: Dock2m4Btlr/Dock2m4Btlr
Genetic Background: C57BL/6J-Dock2m4Btlr

Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m5Btlr/Dock2m5Btlr
Genetic Background: C57BL/6J-Dock2m5Btlr

Allelic Composition: Dock2m5Btlr/Dock2+
Genetic Background: C57BL/6J-Dock2m5Btlr

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd44tm1Hbg/Cd44tm1Hbg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

Allelic Composition: Dock2m2Anu/Dock2m2Anu
Genetic Background: C57BL/6JAnu-Dock2m2Anu

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Irf5tm1Ttg/Irf5tm1Ttg
Genetic Background: B6NHsd.Cg-Irf5tm1Ttg Dock2m1Hsd

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Cryba1tm1a(EUCOMM)Hmgu/Cryba1tm1a(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Dock2m1Hsd/Dock2m1Hsd,Siaetm1.2Avrk/Siaetm1.2Avrk
Genetic Background: B6NHsd.Cg-Siaetm1.2Avrk Dock2m1Hsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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