ENSGALG00000002080


Gallus gallus

Features
Gene ID: ENSGALG00000002080
  
Biological name :DOCK2
  
Synonyms : dedicator of cytokinesis 2 / DOCK2
  
Possible biological names infered from orthology : Dedicator of cytokinesis protein 2 / Q8C3J5 / Q92608
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 3962515
Gene end: 4122445
  
Corresponding Affymetrix probe sets: Gga.12236.1.S1_at (Chicken Array)   Gga.18555.1.S1_s_at (Chicken Array)   GgaAffx.1375.1.S1_s_at (Chicken Array)   GgaAffx.25386.1.S1_at (Chicken Array)   GgaAffx.25386.2.S1_s_at (Chicken Array)   GgaAffx.25386.3.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003234
NCBI entrez gene - 427612     See in Manteia.
RefSeq - XM_425184
swissprot - E1BR42
Ensembl - ENSGALG00000002080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018106.1ENSDARG00000114649Danio rerio
 LO018106.2ENSDARG00000114803Danio rerio
 LO018564.1ENSDARG00000112944Danio rerio
 DOCK2ENSG00000134516Homo sapiens
 Dock2ENSMUSG00000020143Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *ENSGALG0000004225959
DOCK5* / B2RY04* / Q9H7D0* / dedicator of cytokinesis 5* / Dedicator of cytokinesis protein 5 *ENSGALG0000000031154
DOCK3 / dedicator of cytokinesis 3 / Q8IZD9*ENSGALG0000000233536
DOCK4 / dedicator of cytokinesis 4 / P59764* / Q8N1I0* / Dedicator of cytokinesis protein 4 *ENSGALG0000000948024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR026799  Dedicator of cytokinesis protein 2
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001766 membrane raft polarization IEA
 biological_processGO:0001768 establishment of T cell polarity IEA
 biological_processGO:0001771 immunological synapse formation IEA
 biological_processGO:0002277 myeloid dendritic cell activation involved in immune response IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044351 macropinocytosis IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0046631 alpha-beta T cell activation IEA
 biological_processGO:0046633 alpha-beta T cell proliferation IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0042608 T cell receptor binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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