ENSMUSG00000044447


Mus musculus

Features
Gene ID: ENSMUSG00000044447
  
Biological name :Dock5
  
Synonyms : B2RY04 / Dedicator of cytokinesis protein 5 / Dock5
  
Possible biological names infered from orthology : dedicator of cytokinesis 5 / Q9H7D0
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 67752135
Gene end: 67933442
  
Corresponding Affymetrix probe sets: 10421046 (MoGene1.0st)   1425747_at (Mouse Genome 430 2.0 Array)   1430291_at (Mouse Genome 430 2.0 Array)   1439129_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036674
NCBI entrez gene - 68813     See in Manteia.
MGI - MGI:2652871
RefSeq - XM_017316175
RefSeq - NM_177780
RefSeq - XM_011245170
RefSeq Peptide - NP_808448
swissprot - B2RY04
Ensembl - ENSMUSG00000044447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock5ENSDARG00000001968Danio rerio
 ENSGALG00000000311Gallus gallus
 DOCK5ENSG00000147459Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*ENSMUSG0000005832565
Dock2 / Q8C3J5 / Dedicator of cytokinesis protein 2 / Q92608* / dedicator of cytokinesis 2*ENSMUSG0000002014353
Dock4 / P59764 / Dedicator of cytokinesis protein 4 / Q8N1I0* / dedicator of cytokinesis 4*ENSMUSG0000003595436
Dock3 / dedicator of cytokinesis 3 / Q8IZD9*ENSMUSG0000003971636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Prnptm1Rcm/Prnptm1Rcm
Genetic Background: 129P2/OlaHsd-Prnptm1Rcm

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Npr2cn/Npr2cn
Genetic Background: involves: AKR/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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