ENSG00000147459


Homo sapiens

Features
Gene ID: ENSG00000147459
  
Biological name :DOCK5
  
Synonyms : dedicator of cytokinesis 5 / DOCK5 / Q9H7D0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.2
Gene start: 25184723
Gene end: 25418082
  
Corresponding Affymetrix probe sets: 1561276_at (Human Genome U133 Plus 2.0 Array)   1569590_at (Human Genome U133 Plus 2.0 Array)   1570078_a_at (Human Genome U133 Plus 2.0 Array)   215361_at (Human Genome U133 Plus 2.0 Array)   219921_s_at (Human Genome U133 Plus 2.0 Array)   230206_at (Human Genome U133 Plus 2.0 Array)   230207_s_at (Human Genome U133 Plus 2.0 Array)   230263_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000276440
Ensembl peptide - ENSP00000414125
Ensembl peptide - ENSP00000428479
Ensembl peptide - ENSP00000429737
Ensembl peptide - ENSP00000387036
NCBI entrez gene - 80005     See in Manteia.
OMIM - 616904
RefSeq - XM_017013868
RefSeq - XM_011544661
RefSeq - XM_011544662
RefSeq - XM_011544663
RefSeq - XM_017013865
RefSeq - XM_017013866
RefSeq - XM_017013867
RefSeq - NM_001322810
RefSeq - NM_024940
RefSeq Peptide - NP_001309739
RefSeq Peptide - NP_079216
swissprot - H0Y7N4
swissprot - H0YB14
swissprot - Q9H7D0
swissprot - B9A015
Ensembl - ENSG00000147459
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock5ENSDARG00000001968Danio rerio
 ENSGALG00000000311Gallus gallus
 Dock5ENSMUSG00000044447Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK1 / Q14185 / dedicator of cytokinesis 1ENSG0000015076065
DOCK2 / Q92608 / dedicator of cytokinesis 2ENSG0000013451654
DOCK4 / Q8N1I0 / dedicator of cytokinesis 4ENSG0000012851236
DOCK3 / Q8IZD9 / dedicator of cytokinesis 3ENSG0000008853836


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035892  C2 domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IMP
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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