ENSG00000128512


Homo sapiens

Features
Gene ID: ENSG00000128512
  
Biological name :DOCK4
  
Synonyms : dedicator of cytokinesis 4 / DOCK4 / Q8N1I0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.1
Gene start: 111726110
Gene end: 112206411
  
Corresponding Affymetrix probe sets: 1558691_a_at (Human Genome U133 Plus 2.0 Array)   205003_at (Human Genome U133 Plus 2.0 Array)   241313_at (Human Genome U133 Plus 2.0 Array)   244840_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406468
Ensembl peptide - ENSP00000406298
Ensembl peptide - ENSP00000410746
Ensembl peptide - ENSP00000440944
Ensembl peptide - ENSP00000412834
Ensembl peptide - ENSP00000393486
Ensembl peptide - ENSP00000397412
Ensembl peptide - ENSP00000403504
Ensembl peptide - ENSP00000404179
NCBI entrez gene - 9732     See in Manteia.
OMIM - 607679
RefSeq - XM_017012825
RefSeq - NM_014705
RefSeq - XM_006716188
RefSeq - XM_006716189
RefSeq - XM_017012819
RefSeq - XM_017012820
RefSeq - XM_017012821
RefSeq - XM_017012822
RefSeq - XM_017012823
RefSeq - XM_017012824
RefSeq Peptide - NP_055520
swissprot - C9J7D9
swissprot - F5GXW1
swissprot - F8WES4
swissprot - H0Y599
swissprot - H0Y7H7
swissprot - C9J637
swissprot - C9JDB3
swissprot - Q8N1I0
Ensembl - ENSG00000128512
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock4bENSDARG00000024874Danio rerio
 si:dkey-81e3.1ENSDARG00000076213Danio rerio
 DOCK4ENSGALG00000009480Gallus gallus
 Dock4ENSMUSG00000035954Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK3 / Q8IZD9 / dedicator of cytokinesis 3ENSG0000008853857
DOCK1 / Q14185 / dedicator of cytokinesis 1ENSG0000015076035
DOCK2 / Q92608 / dedicator of cytokinesis 2ENSG0000013451634
DOCK5 / Q9H7D0 / dedicator of cytokinesis 5ENSG0000014745934


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035769  Dedicator of cytokinesis 4, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037014  Dedicator of cytokinesis 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IMP
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032420 stereocilium ISS
 cellular_componentGO:0032421 stereocilium bundle ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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