ENSMUSG00000035954


Mus musculus

Features
Gene ID: ENSMUSG00000035954
  
Biological name :Dock4
  
Synonyms : Dedicator of cytokinesis protein 4 / Dock4 / P59764
  
Possible biological names infered from orthology : dedicator of cytokinesis 4 / Q8N1I0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B1
Gene start: 40445952
Gene end: 40846874
  
Corresponding Affymetrix probe sets: 10395466 (MoGene1.0st)   1431114_at (Mouse Genome 430 2.0 Array)   1436405_at (Mouse Genome 430 2.0 Array)   1441462_at (Mouse Genome 430 2.0 Array)   1441469_at (Mouse Genome 430 2.0 Array)   1457146_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047387
Ensembl peptide - ENSMUSP00000152420
NCBI entrez gene - 238130     See in Manteia.
MGI - MGI:1918006
RefSeq - XM_017315054
RefSeq - NM_172803
RefSeq - XM_006515088
RefSeq - XM_006515089
RefSeq - XM_006515090
RefSeq - XM_006515085
RefSeq - XM_006515086
RefSeq - XM_006515087
RefSeq Peptide - NP_766391
swissprot - P59764
swissprot - A0A1Y7VLY2
Ensembl - ENSMUSG00000035954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock4bENSDARG00000024874Danio rerio
 si:dkey-81e3.1ENSDARG00000076213Danio rerio
 DOCK4ENSGALG00000009480Gallus gallus
 DOCK4ENSG00000128512Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock3 / dedicator of cytokinesis 3 / Q8IZD9*ENSMUSG0000003971657
Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*ENSMUSG0000005832535
Dock5 / B2RY04 / Dedicator of cytokinesis protein 5 / Q9H7D0* / dedicator of cytokinesis 5*ENSMUSG0000004444734
Dock2 / Q8C3J5 / Dedicator of cytokinesis protein 2 / Q92608* / dedicator of cytokinesis 2*ENSMUSG0000002014334


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035769  Dedicator of cytokinesis 4, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037014  Dedicator of cytokinesis 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904694 negative regulation of vascular smooth muscle contraction IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032421 stereocilium bundle IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0020373 abnormal blood vessel lumen formation "any anomaly in the process in which a developing blood vessel forms an endothelial lumen through which blood will flow; in vertebrates, the lumen of all blood vessels is lined and formed by endothelial cells; in both vasculogenesis and angiogenesis, lumen formation takes place in a cord of endothelial cells and involves a complex mechanism composed of endothelial cell repulsion at the cell-cell contacts within the endothelial cell cords, junctional rearrangement, and endothelial cell shape change" [GO:0072554, MGI:Anna, PMID:22474612]
Show

Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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