ENSMUSG00000039716


Mus musculus

Features
Gene ID: ENSMUSG00000039716
  
Biological name :Dock3
  
Synonyms : dedicator of cytokinesis 3 / Dock3
  
Possible biological names infered from orthology : Q8IZD9
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 106892825
Gene end: 107231909
  
Corresponding Affymetrix probe sets: 10596583 (MoGene1.0st)   1428852_at (Mouse Genome 430 2.0 Array)   1452930_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130873
Ensembl peptide - ENSMUSP00000047652
Ensembl peptide - ENSMUSP00000127059
Ensembl peptide - ENSMUSP00000131410
Ensembl peptide - ENSMUSP00000131701
NCBI entrez gene - 208869     See in Manteia.
MGI - MGI:2429763
RefSeq - XM_017313261
RefSeq - XM_011242871
RefSeq - XM_011242872
RefSeq - XM_011242873
RefSeq - XM_011242874
RefSeq - XM_011242875
RefSeq - XM_017313260
RefSeq - NM_153413
RefSeq - XM_006511691
RefSeq - XM_011242869
RefSeq - XM_011242870
RefSeq Peptide - NP_700462
swissprot - F7AGL4
swissprot - F7CVM6
swissprot - F8VPQ1
swissprot - F6YXW9
swissprot - F6VMI1
Ensembl - ENSMUSG00000039716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock3ENSDARG00000063180Danio rerio
 DOCK3ENSGALG00000002335Gallus gallus
 DOCK3ENSG00000088538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock4 / P59764 / Dedicator of cytokinesis protein 4 / Q8N1I0* / dedicator of cytokinesis 4*ENSMUSG0000003595456
Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*ENSMUSG0000005832534
Dock5 / B2RY04 / Dedicator of cytokinesis protein 5 / Q9H7D0* / dedicator of cytokinesis 5*ENSMUSG0000004444733
Dock2 / Q8C3J5 / Dedicator of cytokinesis protein 2 / Q92608* / dedicator of cytokinesis 2*ENSMUSG0000002014333


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR026800  Dedicator of cytokinesis 3
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035767  Dedicator of cytokinesis 3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001023 L5 ganglion hypertrophy "increased bulk size of L5 ganglion" [J:34172]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

 MP:0010047 axonal spheroids "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]
Show

Allelic Composition: Ppargtm1.1Auw/Ppargtm1.1Auw
Genetic Background: B6.Cg-Ppargtm1.1Auw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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