ENSG00000088538


Homo sapiens

Features
Gene ID: ENSG00000088538
  
Biological name :DOCK3
  
Synonyms : dedicator of cytokinesis 3 / DOCK3 / Q8IZD9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.2
Gene start: 50675241
Gene end: 51384198
  
Corresponding Affymetrix probe sets: 213482_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000266037
NCBI entrez gene - 1795     See in Manteia.
OMIM - 603123
RefSeq - XM_017005827
RefSeq - NM_004947
RefSeq - XM_017005825
RefSeq - XM_017005826
RefSeq - XM_005264914
RefSeq - XM_005264915
RefSeq - XM_005264916
RefSeq - XM_005264917
RefSeq - XM_005264918
RefSeq - XM_006713008
RefSeq - XM_006713009
RefSeq - XM_006713010
RefSeq - XM_011533441
RefSeq Peptide - NP_004938
swissprot - Q8IZD9
Ensembl - ENSG00000088538
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock3ENSDARG00000063180Danio rerio
 DOCK3ENSGALG00000002335Gallus gallus
 Dock3ENSMUSG00000039716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK4 / Q8N1I0 / dedicator of cytokinesis 4ENSG0000012851255
DOCK1 / Q14185 / dedicator of cytokinesis 1ENSG0000015076035
DOCK5 / Q9H7D0 / dedicator of cytokinesis 5ENSG0000014745934
DOCK2 / Q92608 / dedicator of cytokinesis 2ENSG0000013451633


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR026800  Dedicator of cytokinesis 3
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR032376  Dedicator of cytokinesis, N-terminal domain
 IPR035767  Dedicator of cytokinesis 3, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
NTRK2 activates RAC1
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex






 

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