ENSDARG00000099093


Danio rerio

Features
Gene ID: ENSDARG00000099093
  
Biological name :dock1
  
Synonyms : dedicator of cytokinesis 1 / dock1
  
Possible biological names infered from orthology : Dedicator of cytokinesis protein 1 / Q14185 / Q8BUR4
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 44362897
Gene end: 44759246
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000137898
swissprot - A0A0R4IUA6
ZFIN ID - ZDB-GENE-080108-5
Ensembl - ENSDARG00000099093
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DOCK1ENSGALG00000042259Gallus gallus
 DOCK1ENSG00000150760Homo sapiens
 Dock1ENSMUSG00000058325Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dock5 / dedicator of cytokinesis 5 / B2RY04* / Q9H7D0* / Dedicator of cytokinesis protein 5 *ENSDARG0000000196852
dock4b / dedicator of cytokinesis 4b / DOCK4* / Q8N1I0* / P59764* / dedicator of cytokinesis 4* / Dedicator of cytokinesis protein 4 *ENSDARG0000002487431
dock3 / dedicator of cytokinesis 3 / Q8IZD9*ENSDARG0000006318031
si:dkey-81e3.1 / DOCK4 (1 of many) / DOCK4* / P59764* / Q8N1I0* / dedicator of cytokinesis 4* / Dedicator of cytokinesis protein 4 *ENSDARG0000007621331
CABZ01109481.1ENSDARG000001080389
LO018564.1 / DOCK2* / Q92608* / dedicator of cytokinesis 2*ENSDARG000001129445
CABZ01109480.1ENSDARG000001169944
LO018106.1 / DOCK2* / Q92608* / dedicator of cytokinesis 2*ENSDARG000001146494
LO018106.2 / DOCK2* / Q92608* / dedicator of cytokinesis 2*ENSDARG000001148033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR016024  Armadillo-type fold
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain
 IPR030717  Dedicator of cytokinesis protein 1
 IPR032376  Dedicator of cytokinesis, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007520 myoblast fusion IMP
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk accumulation blood , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros cilium assembly decreased process quality , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule ciliary basal body organization decreased process quality , abnormal
pronephric tubule ciliary basal body mislocalised , abnormal
pronephric tubule ciliary basal body separated from pronephric tubule apical plasma membrane, abnormal
Show

 ZFA:0005034 parachordal vessel parachordal vessel aplastic , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell mononucleate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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