ENSMUSG00000023951


Mus musculus

Features
Gene ID: ENSMUSG00000023951
  
Biological name :Vegfa
  
Synonyms : Q00731 / vascular endothelial growth factor A / Vegfa
  
Possible biological names infered from orthology : P15692
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46016993
Gene end: 46032369
  
Corresponding Affymetrix probe sets: 10451198 (MoGene1.0st)   1420909_at (Mouse Genome 430 2.0 Array)   1451959_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115883
Ensembl peptide - ENSMUSP00000131901
Ensembl peptide - ENSMUSP00000151185
Ensembl peptide - ENSMUSP00000149539
Ensembl peptide - ENSMUSP00000024747
Ensembl peptide - ENSMUSP00000071575
Ensembl peptide - ENSMUSP00000109147
Ensembl peptide - ENSMUSP00000109148
NCBI entrez gene - 22339     See in Manteia.
MGI - MGI:103178
RefSeq - NM_001025257
RefSeq - NM_001287056
RefSeq - NM_001287057
RefSeq - NM_001287058
RefSeq - NM_001317041
RefSeq - NM_009505
RefSeq - NM_001025250
RefSeq Peptide - NP_001020421
RefSeq Peptide - NP_001273985
RefSeq Peptide - NP_001273986
RefSeq Peptide - NP_001273987
RefSeq Peptide - NP_001303970
RefSeq Peptide - NP_033531
RefSeq Peptide - NP_001020428
swissprot - Q00731
swissprot - E9Q4N8
swissprot - F6ZE01
swissprot - F8WH10
swissprot - F8WH81
swissprot - A0A1L1SVG2
swissprot - E9Q4N9
Ensembl - ENSMUSG00000023951
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 O73682ENSDARG00000103542Danio rerio
 vegfabENSDARG00000034700Danio rerio
 VEGFAENSGALG00000010290Gallus gallus
 VEGFAENSG00000112715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pgf / P49764 / placental growth factor / P49763*ENSMUSG0000000479118
Vegfb / P49766 / vascular endothelial growth factor B / P49765*ENSMUSG0000002496214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR027928  Vascular endothelial growth factor, heparin-binding domain
 IPR029034  Cystine-knot cytokine
 IPR036841  Vascular endothelial growth factor, heparin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001946 lymphangiogenesis IGI
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IGI
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IDA
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0002575 basophil chemotaxis ISO
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0022408 negative regulation of cell-cell adhesion IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030224 monocyte differentiation ISS
 biological_processGO:0030225 macrophage differentiation ISS
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process ISO
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0031077 post-embryonic camera-type eye development IMP
 biological_processGO:0031334 positive regulation of protein complex assembly ISS
 biological_processGO:0031954 positive regulation of protein autophosphorylation ISS
 biological_processGO:0032147 activation of protein kinase activity ISO
 biological_processGO:0032793 positive regulation of CREB transcription factor activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0035148 tube formation ISO
 biological_processGO:0035767 endothelial cell chemotaxis ISS
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IGI
 biological_processGO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISS
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway ISO
 biological_processGO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISS
 biological_processGO:0038190 VEGF-activated neuropilin signaling pathway ISO
 biological_processGO:0040007 growth IMP
 biological_processGO:0042327 positive regulation of phosphorylation ISO
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043117 positive regulation of vascular permeability ISO
 biological_processGO:0043129 surfactant homeostasis IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISS
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045601 regulation of endothelial cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045785 positive regulation of cell adhesion ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048739 cardiac muscle fiber development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IDA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IMP
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0050927 positive regulation of positive chemotaxis ISS
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051272 positive regulation of cellular component movement ISS
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISO
 biological_processGO:0060319 primitive erythrocyte differentiation IMP
 biological_processGO:0060346 bone trabecula formation IMP
 biological_processGO:0060426 lung vasculature development IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0060754 positive regulation of mast cell chemotaxis ISO
 biological_processGO:0061304 retinal blood vessel morphogenesis IMP
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
 biological_processGO:0061430 bone trabecula morphogenesis IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071542 dopaminergic neuron differentiation IGI
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance IMP
 biological_processGO:0097475 motor neuron migration IMP
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation ISS
 biological_processGO:1900745 positive regulation of p38MAPK cascade ISO
 biological_processGO:1901492 positive regulation of lymphangiogenesis IDA
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IDA
 biological_processGO:1901727 positive regulation of histone deacetylase activity ISO
 biological_processGO:1902966 positive regulation of protein localization to early endosome ISO
 biological_processGO:1903572 positive regulation of protein kinase D signaling ISO
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule ISS
 molecular_functionGO:0001968 fibronectin binding ISS
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding ISS
 molecular_functionGO:0005172 vascular endothelial growth factor receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0038191 neuropilin binding ISO
 molecular_functionGO:0042056 chemoattractant activity ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding ISS
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0048018 receptor ligand activity ISS
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Tnfrsf11btm1Wss/Tnfrsf11btm1Wss
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000680 absent parathyroid glands "missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tg(SOD1*G93A)1Gur/0,Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Pgrtm1Bwo/Pgrtm1Bwo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgrtm1Bwo/Pgrtm1Bwo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Pgrtm1Bwo/Pgrtm1Bwo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tg(SOD1*G93A)1Gur/0,Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
Genetic Background: B6.129P2-Pik3cdtm1.1Bvan

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Dcttm1(cre)Bee/Dcttm1(cre)Bee
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: at/A,As/As+
Genetic Background: Not Specified

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Dco/Vegfa+
Genetic Background: involves: 129

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
Genetic Background: B6.129P2-Pik3cdtm1.1Bvan

Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm3Gne/Vegfatm3Gne
Genetic Background: involves: C57BL/6N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0002333 abnormal lung compliance "anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cdtm1.1Bvan/Pik3cdtm1.1Bvan
Genetic Background: B6.129P2-Pik3cdtm1.1Bvan

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Kdrtm2Sato/Kdrtm2Sato,Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129

 MP:0002832 coarse hair "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:56826]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003007 ectopic thymus "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003182 decreased pulmonary endothelial cell surface 
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Sox9tm3(cre)Crm/Sox9+,Tg(tetO-Vegfa)1Kesh/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2.1Nagy/Vegfa+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vegfatm1Dco/Vegfa+
Genetic Background: involves: 129

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003543 abnormal vascular endothelial cell differentiation "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Tnfrsf11btm1Wss/Tnfrsf11btm1Wss
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003653 decreased skin turgor "reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003897 abnormal ST interval "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0004112 abnormal arteriole morphology "structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004120 cardiac ischemia "inadequate blood blow to the heart; may cause infarction and is usually caused by coronary artery disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004125 abnormal venule morphology "any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004159 double aortic arch "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004161 cervical aortic arch "aortic arch is located above the level of the clavicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Vegfatm1Dco/Vegfatm1Dco
Genetic Background: involves: 129

Allelic Composition: Vegfatm1Dco/Vegfa+
Genetic Background: involves: 129

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2.1Nagy/Vegfa+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Mpa/Ccr2tm1Mpa,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Lyz2tm1(cre)Ifo/Lyz2+,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0005327 abnormal mesangial cell "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971]
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Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm1Dco/Vegfa+
Genetic Background: involves: 129

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sema3atm1.1Tyag/Sema3atm1.1Tyag,Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Ymd/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA/2J

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006356 abnormal third branchial arch artery morphology "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0008060 abnormal podocyte slit diaphragm morphology "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Sema3atm1.1Tyag/Sema3atm1.1Tyag,Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009392 retinal gliosis "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010453 abnormal coronary vein morphology "any structural anomaly of any of the veins that return blood from the heart muscles to the right atrium through the coronary sinus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010458 pulmonary trunk hypoplasia "underdevelopment or reduced size of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery, usually due to reduced cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010572 persistent right dorsal aorta "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010635 aorta pulmonary collateral arteries "small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus" [PMID:16483787]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010666 abnormal vitelline vein morphology "any structural anomaly of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfa+,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0010911 abnormal pulmonary acinus morphology "any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Vegfatm2Gne/Vegfatm2.1Nagy,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

Allelic Composition: Vegfatm1Dco/Vegfatm1Dco
Genetic Background: involves: 129

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vegfatm2Pec/Vegfatm2Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vegfatm1.1Nagy/Vegfatm1.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Vegfatm4Pec/Vegfatm4Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129/Sv * C57BL/6

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011309 abnormal kidney arterial blood vessel morphology "any structural anomaly of the network of tubes that supply blood to the renal tissues" [MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011312 abnormal kidney afferent arteriole morphology "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011313 abnormal kidney efferent arteriole morphology "any structural anomaly of the blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011316 abnormal kidney interlobular artery morphology "any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011321 abnormal peritubular capillary morphology "any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" [MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011349 abnormal renal glomerulus basement membrane thickness "increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011359 decreased glomerular capillary number "reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles" [MGI:csmith]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011455 absent glomerular endothelium fenestra "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0011758 renal ischemia "inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of a blood vessel; a significant cause of renal dysfunction and cortical and medullary necrosis" [MGI:anna]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011855 abnormal glomerular filtration barrier morphology "any structural anomaly of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte)" [MGI:anna]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0012082 delayed heart development "late onset of the induction and/or differentiation of the heart" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

Allelic Composition: Vegfatm2.1Nagy/Vegfatm2.1Nagy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012310 persistent ductus caroticus "uni- or bilateral persistence of the segment of dorsal aorta located between the third (III) and fourth (IV) aortic arches, which normally regresses early in development; persistence of ductus caroticus with regression of third arch or fourth arch causes the internal and external carotid arteries to arise from the aortic arch on the left side" [MGI:anna]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0020326 dilated capillary "stretched or widened aperture of the luminal space of the small branching blood vessel that form a network between the arterioles and venules" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020329 decreased capillary density "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020331 increased capillary tortuosity "increase in the degree of twisting of capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMCID:PMC3369246]
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002602 Axl / Q00993 / AXL receptor tyrosine kinase / P30530*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000020312 Shc2 / Q8BMC3 / SHC (Src homology 2 domain containing) transforming protein 2 / P98077* / SHC adaptor protein 2*  / reaction / complex
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / reaction / complex
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / reaction / complex
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / reaction / complex
 ENSMUSG00000028071 Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*  / complex / reaction
 ENSMUSG00000029648 Flt1 / fms related tyrosine kinase 1 / P17948*  / reaction / complex
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction






 

2 s.

 
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