MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0000930 | wavy neural tube | "undulations in the embryonic neural tube" [J:37888] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0001726 | abnormal allantois | "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002084 | abnormal developmental patterning | "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Nck2tm1Paw/Nck2tm1Paw Genetic Background: involves: 129/Ola * ICR
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MP:0002199 | abnormal brain commissure morphology | "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0002961 | abnormal axon guidance | "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0003880 | abnormal central pattern generator function | "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0004557 | dilated allantois | "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0004712 | notochord degeneration | "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0008059 | abnormal podocyte foot process morphology | "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0008139 | fused podocyte foot processes | "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0008503 | abnormal spinal cord gray matter morphology | "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0009657 | failure of chorioallantoic fusion | "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0009677 | abnormal spinal cord dorsal column morphology | "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Bmi1tm1Brn/Bmi1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0011402 | renal cast | "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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MP:0011856 | abnormal glomerular filtration barrier function | "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna] |
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)
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