ENSMUSG00000004837


Mus musculus

Features
Gene ID: ENSMUSG00000004837
  
Biological name :Grap
  
Synonyms : Grap / GRB2-related adapter protein / Q9CX99
  
Possible biological names infered from orthology : GRAPL / GRB2-related adaptor protein / GRB2 related adaptor protein like / Q13588 / Q8TC17
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 61653265
Gene end: 61672784
  
Corresponding Affymetrix probe sets: 10376796 (MoGene1.0st)   1429387_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004959
NCBI entrez gene - 71520     See in Manteia.
MGI - MGI:1918770
RefSeq - NM_027817
RefSeq Peptide - NP_082093
swissprot - Q9CX99
Ensembl - ENSMUSG00000004837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grapaENSDARG00000005414Danio rerio
 grapbENSDARG00000022668Danio rerio
 GRAPENSGALG00000005094Gallus gallus
 GRAPENSG00000154016Homo sapiens
 GRAPLENSG00000189152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*ENSMUSG0000005992357
Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*ENSMUSG0000004235147
Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*ENSMUSG0000003247526
Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*ENSMUSG0000006687725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035645  GRAP, N-terminal SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Camptm1Rlg/Camptm1Rlg
Genetic Background: 129X1/SvJ-Camptm1Rlg

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camptm1Rlg/Camptm1Rlg
Genetic Background: 129X1/SvJ-Camptm1Rlg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex






 

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