ENSG00000154016


Homo sapiens

Features
Gene ID: ENSG00000154016
  
Biological name :GRAP
  
Synonyms : GRAP / GRB2-related adaptor protein / Q13588
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 19020673
Gene end: 19047637
  
Corresponding Affymetrix probe sets: 206620_at (Human Genome U133 Plus 2.0 Array)   229726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464328
Ensembl peptide - ENSP00000284154
Ensembl peptide - ENSP00000378997
Ensembl peptide - ENSP00000459833
NCBI entrez gene - 10750     See in Manteia.
OMIM - 604330
RefSeq - XM_017024030
RefSeq - NM_006613
RefSeq - XM_017024029
RefSeq Peptide - NP_001317077
RefSeq Peptide - NP_006604
swissprot - A8MW78
swissprot - Q13588
swissprot - I3L2P9
swissprot - J3QRP9
Ensembl - ENSG00000154016
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grapaENSDARG00000005414Danio rerio
 grapbENSDARG00000022668Danio rerio
 GRAPENSGALG00000005094Gallus gallus
 GrapENSMUSG00000004837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB2 / P62993 / growth factor receptor bound protein 2ENSG0000017788559
GRAPL / Q8TC17 / GRB2 related adaptor protein likeENSG0000018915250
GRAP2 / O75791 / GRB2-related adaptor protein 2ENSG0000010035147
NCK1 / P16333 / NCK adaptor protein 1ENSG0000015809226
NCK2 / O43639 / NCK adaptor protein 2ENSG0000007105124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR035645  GRAP, N-terminal SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr