ENSG00000071051


Homo sapiens

Features
Gene ID: ENSG00000071051
  
Biological name :NCK2
  
Synonyms : NCK2 / NCK adaptor protein 2 / O43639
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.2
Gene start: 105744897
Gene end: 105894274
  
Corresponding Affymetrix probe sets: 203315_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377017
Ensembl peptide - ENSP00000233154
Ensembl peptide - ENSP00000377018
Ensembl peptide - ENSP00000431109
Ensembl peptide - ENSP00000410428
Ensembl peptide - ENSP00000408040
NCBI entrez gene - 8440     See in Manteia.
OMIM - 604930
RefSeq - XM_017005105
RefSeq - NM_001004720
RefSeq - NM_001004722
RefSeq - NM_003581
RefSeq - XM_006712797
RefSeq - XM_011511991
RefSeq - XM_011511992
RefSeq - XM_017005103
RefSeq - XM_017005104
RefSeq Peptide - NP_003572
RefSeq Peptide - NP_001004720
RefSeq Peptide - NP_001004722
swissprot - E9PEE2
swissprot - A0A0S2Z4M6
swissprot - O43639
swissprot - E7ERP6
swissprot - E7EPF5
Ensembl - ENSG00000071051
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nck2aENSDARG00000018206Danio rerio
 nck2bENSDARG00000043361Danio rerio
 NCK2ENSGALG00000016799Gallus gallus
 Nck2ENSMUSG00000066877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCK1 / P16333 / NCK adaptor protein 1ENSG0000015809269
GRAP2 / O75791 / GRB2-related adaptor protein 2ENSG0000010035114
GRAP / Q13588 / GRB2-related adaptor proteinENSG0000015401614
GRB2 / P62993 / growth factor receptor bound protein 2ENSG0000017788513
GRAPL / Q8TC17 / GRB2 related adaptor protein likeENSG0000018915211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR035559  Nck2, SH3 domain 1
 IPR035560  Nck2, SH3 domain 2
 IPR035561  Nck2, SH3 domain 3
 IPR035883  Nck2, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007172 signal complex assembly NAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0036493 positive regulation of translation in response to endoplasmic reticulum stress IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005070 SH3/SH2 adaptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008093 cytoskeletal adaptor activity NAS
 molecular_functionGO:0030159 receptor signaling complex scaffold activity NAS
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
Regulation of cortical dendrite branching


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex
 ENSG00000100485 SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex
 ENSG00000187122 SLIT1 / O75093 / slit guidance ligand 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / reaction / complex
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / reaction / complex
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / reaction / complex
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / complex / reaction






 

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