ENSG00000187122


Homo sapiens

Features
Gene ID: ENSG00000187122
  
Biological name :SLIT1
  
Synonyms : O75093 / SLIT1 / slit guidance ligand 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 96998038
Gene end: 97185920
  
Corresponding Affymetrix probe sets: 208221_s_at (Human Genome U133 Plus 2.0 Array)   213601_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000266058
Ensembl peptide - ENSP00000315005
Ensembl peptide - ENSP00000360080
Ensembl peptide - ENSP00000360109
NCBI entrez gene - 6585     See in Manteia.
OMIM - 603742
RefSeq - NM_003061
RefSeq Peptide - NP_003052
swissprot - O75093
swissprot - Q5T0V0
swissprot - Q5T0V2
swissprot - Q5T0V4
Ensembl - ENSG00000187122
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit1aENSDARG00000044954Danio rerio
 slit1bENSDARG00000099446Danio rerio
 SLIT1ENSGALG00000042871Gallus gallus
 Slit1ENSMUSG00000025020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLIT2 / O94813 / slit guidance ligand 2ENSG0000014514765
SLIT3 / O75094 / slit guidance ligand 3ENSG0000018434759
CRB1 / P82279 / crumbs 1, cell polarity complex componentENSG0000013437616
CRB2 / Q5IJ48 / crumbs 2, cell polarity complex componentENSG0000014820414
DNER / Q8NFT8 / delta/notch like EGF repeat containingENSG0000018795710
DLK2 / Q6UY11 / delta like non-canonical Notch ligand 2ENSG000001714627
DLL3 / Q9NYJ7 / delta like canonical Notch ligand 3ENSG000000909327
DLK1 / P80370 / delta like non-canonical Notch ligand 1ENSG000001855596


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003645  Follistatin-like, N-terminal
 IPR006207  Cystine knot, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007097 nuclear migration IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IEA
 biological_processGO:0022029 telencephalon cell migration IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0033563 dorsal/ventral axon guidance IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0048846 axon extension involved in axon guidance IDA
 biological_processGO:0048853 forebrain morphogenesis NAS
 biological_processGO:0050919 negative chemotaxis IDA
 biological_processGO:0051964 negative regulation of synapse assembly ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048495 Roundabout binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Signaling by ROBO receptors
Regulation of commissural axon pathfinding by SLIT and ROBO
Regulation of cortical dendrite branching
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000125848 FLRT3 / Q9NZU0 / fibronectin leucine rich transmembrane protein 3  / reaction / complex
 ENSG00000187122 SLIT1 / O75093 / slit guidance ligand 1  / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex






 

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