ENSDARG00000044954


Danio rerio

Features
Gene ID: ENSDARG00000044954
  
Biological name :slit1a
  
Synonyms : slit1a / slit homolog 1a (Drosophila)
  
Possible biological names infered from orthology : O75093 / Q80TR4 / SLIT1 / slit guidance ligand 1 / Slit homolog 1 protein
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 555321
Gene end: 638485
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000105194
Ensembl peptide - ENSDARP00000066079
NCBI entrez gene - 556123     See in Manteia.
RefSeq - NM_001034968
RefSeq Peptide - NP_001030140
swissprot - B8A498
ZFIN ID - ZDB-GENE-030722-3
Ensembl - ENSDARG00000044954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLIT1ENSGALG00000042871Gallus gallus
 SLIT1ENSG00000187122Homo sapiens
 Slit1ENSMUSG00000025020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slit1b / slit homolog 1b (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000009944669
slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*ENSDARG0000000424663
slit3 / slit homolog 3 (Drosophila) / Q9WVB4* / O75094* / slit guidance ligand 3* / Slit homolog 3 protein *ENSDARG0000003426856
crb1 / crumbs family member 1, photoreceptor morphogenesis associated / 1 * / P82279* / Q8VHS2* / crumbs 1, cell polarity complex component*ENSDARG0000010050616
crb2a / crumbs family member 2a / 2 * / CRB2* / Q5IJ48* / Q80YA8* / crumbs 2, cell polarity complex component*ENSDARG0000006010614
crb2b / crumbs family member 2b / CRB2* / Q5IJ48* / crumbs 2, cell polarity complex component*ENSDARG000000600819
dner / delta/notch-like EGF repeat containing / Q8NFT8*ENSDARG000000610319
dlk2 / delta-like 2 homolog (Drosophila) / 2 * / Q6UY11* / Q8K1E3* / delta like non-canonical Notch ligand 2*ENSDARG000000762475
CABZ01102109.1 / DLK1* / P80370* / delta like non-canonical Notch ligand 1*ENSDARG000001142264
CR456624.1 / DLL3* / O88516* / Q9NYJ7* / Delta-like protein 3 * / delta like canonical Notch ligand 3*ENSDARG000000795194


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006207  Cystine knot, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0045773 positive regulation of axon extension IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000059 postoptic commissure postoptic commissure decreased width , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell axon physical object quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr