ENSDARG00000060106


Danio rerio

Features
Gene ID: ENSDARG00000060106
  
Biological name :crb2a
  
Synonyms : crb2a / crumbs family member 2a
  
Possible biological names infered from orthology : 2 / CRB2 / crumbs 2, cell polarity complex component / Q5IJ48 / Q80YA8
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 8478774
Gene end: 8513192
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000078813
NCBI entrez gene - 723994     See in Manteia.
RefSeq - NM_001045299
RefSeq Peptide - NP_001038764
swissprot - Q1A5L2
ZFIN ID - ZDB-GENE-060612-1
Ensembl - ENSDARG00000060106
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRB2ENSGALG00000001169Gallus gallus
 CRB2ENSG00000148204Homo sapiens
 2 ENSMUSG00000035403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
crb1 / crumbs family member 1, photoreceptor morphogenesis associated / 1 * / P82279* / Q8VHS2* / crumbs 1, cell polarity complex component*ENSDARG0000010050635
crb2b / crumbs family member 2b / CRB2* / Q5IJ48* / crumbs 2, cell polarity complex component*ENSDARG0000006008132
slit3 / slit homolog 3 (Drosophila) / Q9WVB4* / O75094* / slit guidance ligand 3* / Slit homolog 3 protein *ENSDARG0000003426815
slit1b / slit homolog 1b (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000009944615
slit1a / slit homolog 1a (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000004495415
slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*ENSDARG0000000424615
dner / delta/notch-like EGF repeat containing / Q8NFT8*ENSDARG0000006103111
dlk2 / delta-like 2 homolog (Drosophila) / 2 * / Q6UY11* / Q8K1E3* / delta like non-canonical Notch ligand 2*ENSDARG000000762476
CR456624.1 / DLL3* / O88516* / Q9NYJ7* / Delta-like protein 3 * / delta like canonical Notch ligand 3*ENSDARG000000795195
CABZ01102109.1 / DLK1* / P80370* / delta like non-canonical Notch ligand 1*ENSDARG000001142264


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IPI
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0045176 apical protein localization IGI
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain shape , abnormal
brain morphology , abnormal
Show

 ZFA:0000029 hindbrain hindbrain establishment or maintenance of epithelial cell apical/basal polarity process quality , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer disorganized , abnormal
Show

 ZFA:0000101 diencephalon diencephalon establishment or maintenance of epithelial cell apical/basal polarity process quality , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased diameter , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer distributed , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium patchy , abnormal
retinal pigmented epithelium poorly differentiated , abnormal
Show

 ZFA:0000152 retina retina apoptotic , abnormal
retina morphology , abnormal
retina absent , abnormal
retina disorganized , abnormal
Show

 ZFA:0000166 lateral crista lateral crista cilium decreased length , abnormal
lateral crista ciliary shaft spatial pattern , abnormal
lateral crista ciliary shaft increased amount , abnormal
lateral crista ciliary shaft has extra parts of type lateral crista intraciliary transport particle, abnormal
lateral crista intraciliary transport particle increased amount , abnormal
lateral crista ciliary shaft has extra parts of type lateral crista intraciliary transport particle, exacerbated
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000554 olfactory epithelium olfactory epithelium cilium decreased length , abnormal
olfactory epithelium ciliary shaft spatial pattern , abnormal
olfactory epithelium ciliary shaft increased amount , abnormal
olfactory epithelium cilium decreased length , exacerbated
olfactory epithelium intraciliary transport particle increased amount , abnormal
Show

 ZFA:0000640 cornea cornea anatomical surface structure , abnormal
Show

 ZFA:0001135 neural tube neural tube apical junction complex structure , abnormal
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 ZFA:0001202 optic cup optic cup absent , abnormal
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 ZFA:0001261 ventricular system ventricular system decreased size , abnormal
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 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer patchy , abnormal
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 ZFA:0001330 retinal outer plexiform layer retinal outer plexiform layer patchy , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer distributed , abnormal
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 ZFA:0001683 corneal epithelium corneal epithelium saccular , abnormal
corneal epithelium desmosome decreased amount , abnormal
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 ZFA:0001685 corneal stroma corneal stroma disorganized , abnormal
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 ZFA:0009090 pigment cell pigment cell quality , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell decreased adhesivity , abnormal
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 ZFA:0009264 corneal epithelial cell corneal epithelial cell cellular adhesivity corneal epithelial cell , abnormal
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 ZFA:0009275 retinal rod cell retinal rod cell disorganized , abnormal
retinal rod cell increased distribution , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell positional polarity , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell disorganized , abnormal
retinal ganglion cell increased distribution , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell apical junction complex structure , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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