ENSDARG00000004246


Danio rerio

Features
Gene ID: ENSDARG00000004246
  
Biological name :slit2
  
Synonyms : slit2 / slit homolog 2 (Drosophila)
  
Possible biological names infered from orthology : O94813 / Q9R1B9 / slit guidance ligand 2
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 23783349
Gene end: 23912788
  
Corresponding Affymetrix probe sets: Dr.10489.1.S1_at (Zebrafish Array)   Dr.20260.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000154786
Ensembl peptide - ENSDARP00000155570
Ensembl peptide - ENSDARP00000026343
Ensembl peptide - ENSDARP00000132002
Ensembl peptide - ENSDARP00000145580
NCBI entrez gene - 80353     See in Manteia.
RefSeq - XM_021475861
swissprot - A0A0R4IFT2
swissprot - F1QQE4
ZFIN ID - ZDB-GENE-010306-3
Ensembl - ENSDARG00000004246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLIT2ENSGALG00000041121Gallus gallus
 SLIT2ENSG00000145147Homo sapiens
 Slit2ENSMUSG00000031558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slit1a / slit homolog 1a (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000004495463
slit3 / slit homolog 3 (Drosophila) / Q9WVB4* / O75094* / slit guidance ligand 3* / Slit homolog 3 protein *ENSDARG0000003426862
slit1b / slit homolog 1b (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000009944659
crb1 / crumbs family member 1, photoreceptor morphogenesis associated / 1 * / P82279* / Q8VHS2* / crumbs 1, cell polarity complex component*ENSDARG0000010050616
crb2a / crumbs family member 2a / 2 * / CRB2* / Q5IJ48* / Q80YA8* / crumbs 2, cell polarity complex component*ENSDARG0000006010615
crb2b / crumbs family member 2b / CRB2* / Q5IJ48* / crumbs 2, cell polarity complex component*ENSDARG000000600819
dner / delta/notch-like EGF repeat containing / Q8NFT8*ENSDARG000000610319
dlk2 / delta-like 2 homolog (Drosophila) / 2 * / Q6UY11* / Q8K1E3* / delta like non-canonical Notch ligand 2*ENSDARG000000762476
CR456624.1 / DLL3* / O88516* / Q9NYJ7* / Delta-like protein 3 * / delta like canonical Notch ligand 3*ENSDARG000000795194
CABZ01102109.1 / DLK1* / P80370* / delta like non-canonical Notch ligand 1*ENSDARG000001142264


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003645  Follistatin-like, N-terminal
 IPR006207  Cystine knot, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001763 morphogenesis of a branching structure IMP
 biological_processGO:0003262 endocardial progenitor cell migration to the midline involved in heart field formation IGI
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007414 axonal defasciculation IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0030517 negative regulation of axon extension IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IBA
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001320 endocardium endocardium mislocalised , abnormal
endocardium cell malformed , abnormal
Show

 ZFA:0001657 supraoptic tract supraoptic tract axon extension process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016153 dag1 / dystroglycan 1 / Q14118* / Q62165* / Dystroglycan Alpha-dystroglycan Beta-dystroglycan*  / complex / reaction
 ENSDARG00000077410 myo9b / myosin IXb / Q13459*  / reaction / complex
 ENSDARG00000032049 enah / enabled homolog (Drosophila) / Q03173* / Q8N8S7* / ENAH, actin regulator*  / complex
 ENSDARG00000078313 MYO9B / si:zfos-588f8.1 / Q13459* / myosin IXB*  / complex / reaction
 ENSDARG00000017105 vaspb / vasodilator stimulated phosphoprotein b / VASP* / P50552* / P70460* / vasodilator stimulated phosphoprotein*  / complex
 ENSDARG00000035650 evla / Enah/Vasp-like a / EVL* / Q9UI08* / P70429* / Enah/Vasp-like* / Ena/VASP-like protein *  / complex
 ENSDARG00000013841 abl2 / c-abl oncogene 2, non-receptor tyrosine kinase / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*  / reaction / complex
 ENSDARG00000037116 cxcl12a / chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*  / complex / reaction
 ENSDARG00000055100 cxcl12b / chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*  / complex / reaction
 ENSDARG00000041959 cxcr4b / chemokine (C-X-C motif), receptor 4b / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*  / reaction / complex
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction / complex






 

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