ENSG00000145147


Homo sapiens

Features
Gene ID: ENSG00000145147
  
Biological name :SLIT2
  
Synonyms : O94813 / SLIT2 / slit guidance ligand 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p15.31
Gene start: 20253260
Gene end: 20620561
  
Corresponding Affymetrix probe sets: 209897_s_at (Human Genome U133 Plus 2.0 Array)   228850_s_at (Human Genome U133 Plus 2.0 Array)   230130_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426356
Ensembl peptide - ENSP00000425609
Ensembl peptide - ENSP00000427548
Ensembl peptide - ENSP00000482129
Ensembl peptide - ENSP00000273739
Ensembl peptide - ENSP00000421975
Ensembl peptide - ENSP00000422261
Ensembl peptide - ENSP00000422591
Ensembl peptide - ENSP00000423179
NCBI entrez gene - 9353     See in Manteia.
OMIM - 603746
RefSeq - XM_017008845
RefSeq - NM_001289135
RefSeq - NM_001289136
RefSeq - NM_004787
RefSeq - XM_005248211
RefSeq - XM_006713986
RefSeq - XM_011513909
RefSeq - XM_011513910
RefSeq Peptide - NP_001276064
RefSeq Peptide - NP_001276065
RefSeq Peptide - NP_004778
swissprot - E9PCX4
swissprot - F5H0U4
swissprot - H0Y968
swissprot - H0Y9Z6
swissprot - O94813
swissprot - X6R3P0
swissprot - A0A087WYV5
Ensembl - ENSG00000145147
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit2ENSDARG00000004246Danio rerio
 SLIT2ENSGALG00000041121Gallus gallus
 Slit2ENSMUSG00000031558Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLIT1 / O75093 / slit guidance ligand 1ENSG0000018712266
SLIT3 / O75094 / slit guidance ligand 3ENSG0000018434766
CRB1 / P82279 / crumbs 1, cell polarity complex componentENSG0000013437616
CRB2 / Q5IJ48 / crumbs 2, cell polarity complex componentENSG0000014820414
DNER / Q8NFT8 / delta/notch like EGF repeat containingENSG0000018795711
DLL3 / Q9NYJ7 / delta like canonical Notch ligand 3ENSG000000909328
DLK2 / Q6UY11 / delta like non-canonical Notch ligand 2ENSG000001714626
DLK1 / P80370 / delta like non-canonical Notch ligand 1ENSG000001855596


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003645  Follistatin-like, N-terminal
 IPR006207  Cystine knot, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0002689 negative regulation of leukocyte chemotaxis IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0008045 motor neuron axon guidance IDA
 biological_processGO:0010593 negative regulation of lamellipodium assembly IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IDA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IDA
 biological_processGO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA
 biological_processGO:0021972 corticospinal neuron axon guidance through spinal cord IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030837 negative regulation of actin filament polymerization IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IDA
 biological_processGO:0032870 cellular response to hormone stimulus IEP
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0035385 Roundabout signaling pathway IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043116 negative regulation of vascular permeability IDA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048846 axon extension involved in axon guidance IDA
 biological_processGO:0050772 positive regulation of axonogenesis TAS
 biological_processGO:0050919 negative chemotaxis IMP
 biological_processGO:0050929 induction of negative chemotaxis IDA
 biological_processGO:0051058 negative regulation of small GTPase mediated signal transduction IDA
 biological_processGO:0051414 response to cortisol IEP
 biological_processGO:0061364 apoptotic process involved in luteolysis IEP
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IMP
 biological_processGO:0071504 cellular response to heparin IDA
 biological_processGO:0071672 negative regulation of smooth muscle cell chemotaxis IDA
 biological_processGO:0071676 negative regulation of mononuclear cell migration IDA
 biological_processGO:0090024 negative regulation of neutrophil chemotaxis IDA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis ISS
 biological_processGO:0090260 negative regulation of retinal ganglion cell axon guidance IDA
 biological_processGO:0090288 negative regulation of cellular response to growth factor stimulus IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005095 GTPase inhibitor activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043237 laminin-1 binding IDA
 molecular_functionGO:0043394 proteoglycan binding IPI
 molecular_functionGO:0048495 Roundabout binding IPI


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Signaling by ROBO receptors
Activation of RAC1
Regulation of commissural axon pathfinding by SLIT and ROBO
Inactivation of CDC42 and RAC1
Role of ABL in ROBO-SLIT signaling
SLIT2:ROBO1 increases RHOA activity
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121966 CXCR4 / P61073 / C-X-C motif chemokine receptor 4  / reaction / complex
 ENSG00000112186 CAP2 / P40123 / cyclase associated actin cytoskeleton regulatory protein 2  / reaction / complex
 ENSG00000074054 CLASP1 / Q7Z460 / cytoplasmic linker associated protein 1  / reaction / complex
 ENSG00000063660 GPC1 / P35052 / glypican 1  / complex / reaction
 ENSG00000163539 CLASP2 / O75122 / cytoplasmic linker associated protein 2  / complex / reaction
 ENSG00000173402 DAG1 / Q14118 / dystroglycan 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000196220 O43295 / SRGAP3 / SLIT-ROBO Rho GTPase activating protein 3  / complex / reaction
 ENSG00000196935 Q7Z6B7 / SRGAP1 / SLIT-ROBO Rho GTPase activating protein 1  / reaction / complex
 ENSG00000143322 ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000154380 ENAH / Q8N8S7 / ENAH, actin regulator  / reaction / complex
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000147799 Q9C0H5 / ARHGAP39 / Rho GTPase activating protein 39  / reaction / complex
 ENSG00000266028 O75044 / SRGAP2 / SLIT-ROBO Rho GTPase activating protein 2  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000196405 EVL / Q9UI08 / Enah/Vasp-like  / complex / reaction
 ENSG00000125753 VASP / P50552 / vasodilator stimulated phosphoprotein  / complex / reaction
 ENSG00000099331 MYO9B / Q13459 / myosin IXB  / complex / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000100485 SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000107562 CXCL12 / P48061 / C-X-C motif chemokine ligand 12  / reaction / complex
 ENSG00000131236 CAP1 / Q01518 / cyclase associated actin cytoskeleton regulatory protein 1  / reaction / complex
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / reaction / complex






 

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