ENSG00000112186


Homo sapiens

Features
Gene ID: ENSG00000112186
  
Biological name :CAP2
  
Synonyms : CAP2 / cyclase associated actin cytoskeleton regulatory protein 2 / P40123
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.3
Gene start: 17393216
Gene end: 17557792
  
Corresponding Affymetrix probe sets: 212551_at (Human Genome U133 Plus 2.0 Array)   212554_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418604
Ensembl peptide - ENSP00000483435
Ensembl peptide - ENSP00000482279
Ensembl peptide - ENSP00000420615
Ensembl peptide - ENSP00000419906
Ensembl peptide - ENSP00000229922
Ensembl peptide - ENSP00000368275
Ensembl peptide - ENSP00000417208
Ensembl peptide - ENSP00000417705
NCBI entrez gene - 10486     See in Manteia.
RefSeq - NM_006366
RefSeq - XM_011514233
RefSeq Peptide - NP_006357
swissprot - A0A087WZ15
swissprot - F8WDB9
swissprot - E9PDI2
swissprot - P40123
swissprot - F8WEW0
swissprot - B7Z385
swissprot - A0A087X0J3
Ensembl - ENSG00000112186
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cap2ENSDARG00000104478Danio rerio
 CAP2ENSGALG00000012715Gallus gallus
 Cap2ENSMUSG00000021373Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAP1 / Q01518 / cyclase associated actin cytoskeleton regulatory protein 1ENSG0000013123663


Protein motifs (from Interpro)
Interpro ID Name
 IPR001837  Adenylate cyclase-associated CAP
 IPR006599  CARP motif
 IPR013912  Adenylate cyclase-associated CAP, C-terminal
 IPR013992  Adenylate cyclase-associated CAP, N-terminal
 IPR017901  C-CAP/cofactor C-like domain
 IPR018106  CAP, conserved site, N-terminal
 IPR028417  CAP, conserved site, C-terminal
 IPR028418  Adenylyl cyclase-associated protein CAP2
 IPR036222  Adenylate cyclase-associated CAP, N-terminal domain superfamily
 IPR036223  Adenylate cyclase-associated CAP, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0008154 actin polymerization or depolymerization IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IBA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Role of ABL in ROBO-SLIT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143322 ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr