ENSG00000143322


Homo sapiens

Features
Gene ID: ENSG00000143322
  
Biological name :ABL2
  
Synonyms : ABL2 / ABL proto-oncogene 2, non-receptor tyrosine kinase / P42684
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q25.2
Gene start: 179099327
Gene end: 179229684
  
Corresponding Affymetrix probe sets: 206411_s_at (Human Genome U133 Plus 2.0 Array)   226893_at (Human Genome U133 Plus 2.0 Array)   231907_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427562
Ensembl peptide - ENSP00000339209
Ensembl peptide - ENSP00000356595
Ensembl peptide - ENSP00000375897
Ensembl peptide - ENSP00000423413
Ensembl peptide - ENSP00000423578
Ensembl peptide - ENSP00000424697
Ensembl peptide - ENSP00000426831
NCBI entrez gene - 27     See in Manteia.
OMIM - 164690
RefSeq - XM_017001035
RefSeq - NM_001136000
RefSeq - NM_001136001
RefSeq - NM_001168236
RefSeq - NM_001168237
RefSeq - NM_001168238
RefSeq - NM_001168239
RefSeq - NM_005158
RefSeq - NM_007314
RefSeq - XM_005245088
RefSeq Peptide - NP_001129473
RefSeq Peptide - NP_001161709
RefSeq Peptide - NP_001161710
RefSeq Peptide - NP_001161711
RefSeq Peptide - NP_005149
RefSeq Peptide - NP_009298
RefSeq Peptide - NP_001161708
RefSeq Peptide - NP_001129472
swissprot - P42684
Ensembl - ENSG00000143322
  
Related genetic diseases (OMIM): 164690 - Leukemia, acute myeloid, with eosinophilia
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abl2ENSDARG00000013841Danio rerio
 ENSGALG00000030357Gallus gallus
 Abl2ENSMUSG00000026596Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700753
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560517
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067117
TXK / P42681 / TXK tyrosine kinaseENSG0000007496615
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201015
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326315
FER / P16591 / FER tyrosine kinaseENSG0000015142215
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726415
CSK / P41240 / C-terminal Src kinaseENSG0000010365315
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035837  Tyrosine-protein kinase ABL, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0010506 regulation of autophagy TAS
 biological_processGO:0010863 positive regulation of phospholipase C activity IMP
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030100 regulation of endocytosis TAS
 biological_processGO:0030155 regulation of cell adhesion TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IDA
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:2000145 regulation of cell motility TAS
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0003785 actin monomer binding TAS
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051015 actin filament binding TAS


Pathways (from Reactome)
Pathway description
Role of ABL in ROBO-SLIT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112186 CAP2 / P40123 / cyclase associated actin cytoskeleton regulatory protein 2  / reaction / complex
 ENSG00000074054 CLASP1 / Q7Z460 / cytoplasmic linker associated protein 1  / complex / reaction
 ENSG00000163539 CLASP2 / O75122 / cytoplasmic linker associated protein 2  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / complex / reaction
 ENSG00000131236 CAP1 / Q01518 / cyclase associated actin cytoskeleton regulatory protein 1  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex






 

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