ENSG00000074966


Homo sapiens

Features
Gene ID: ENSG00000074966
  
Biological name :TXK
  
Synonyms : P42681 / TXK / TXK tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p12
Gene start: 48066393
Gene end: 48134256
  
Corresponding Affymetrix probe sets: 206828_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264316
Ensembl peptide - ENSP00000424070
Ensembl peptide - ENSP00000423481
Ensembl peptide - ENSP00000422798
Ensembl peptide - ENSP00000422139
NCBI entrez gene - 7294     See in Manteia.
OMIM - 600058
RefSeq - XM_011513747
RefSeq - XM_017008581
RefSeq - XM_017008580
RefSeq - XM_011513748
RefSeq - NM_003328
RefSeq Peptide - NP_003319
swissprot - P42681
swissprot - E7EQN8
swissprot - D6R9F2
swissprot - D6RA14
swissprot - D6RBM7
Ensembl - ENSG00000074966
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 txkENSDARG00000015068Danio rerio
 TXKENSGALG00000014127Gallus gallus
 TxkENSMUSG00000054892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560557
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326354
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067151
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201046
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332235
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700735
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251131
CSK / P41240 / C-terminal Src kinaseENSG0000010365331
FER / P16591 / FER tyrosine kinaseENSG0000015142230
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035579  Tyrosine-protein kinase TXK, SH3 domain
 IPR035870  Tyrosine-protein kinase TXK, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production ISS
 biological_processGO:0002250 adaptive immune response ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity ISS
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0010543 regulation of platelet activation IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042246 tissue regeneration IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050852 T cell receptor signaling pathway ISS
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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