ENSG00000151422


Homo sapiens

Features
Gene ID: ENSG00000151422
  
Biological name :FER
  
Synonyms : FER / FER tyrosine kinase / P16591
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q21.3
Gene start: 108747822
Gene end: 109196841
  
Corresponding Affymetrix probe sets: 206412_at (Human Genome U133 Plus 2.0 Array)   227579_at (Human Genome U133 Plus 2.0 Array)   232064_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486048
Ensembl peptide - ENSP00000394297
Ensembl peptide - ENSP00000421951
Ensembl peptide - ENSP00000484767
Ensembl peptide - ENSP00000281092
NCBI entrez gene - 2241     See in Manteia.
OMIM - 176942
RefSeq - XM_017009233
RefSeq - XM_011543270
RefSeq - XM_011543271
RefSeq - XM_011543272
RefSeq - XM_011543276
RefSeq - XM_017009229
RefSeq - XM_017009230
RefSeq - XM_017009231
RefSeq - XM_017009232
RefSeq - NM_001308028
RefSeq - NM_001308031
RefSeq - NM_005246
RefSeq - XM_011543266
RefSeq - XM_011543267
RefSeq - XM_011543269
RefSeq Peptide - NP_001294960
RefSeq Peptide - NP_005237
RefSeq Peptide - NP_001294957
swissprot - A0A0D9SEV4
swissprot - D6RAF9
swissprot - P16591
swissprot - W0S0X4
swissprot - W0S4B9
Ensembl - ENSG00000151422
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ferENSDARG00000012196Danio rerio
 FERENSGALG00000000273Gallus gallus
 FerENSMUSG00000000127Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251151
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201022
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332222
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700722
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326322
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067121
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560521
CSK / P41240 / C-terminal Src kinaseENSG0000010365319
TXK / P42681 / TXK tyrosine kinaseENSG0000007496619
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR028539  Tyrosine-protein kinase Fer
 IPR031160  F-BAR domain
 IPR035849  Fes/Fps/Fer, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037452  Tyrosine-protein kinase Fer, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0001932 regulation of protein phosphorylation ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010591 regulation of lamellipodium assembly IDA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0033007 negative regulation of mast cell activation involved in immune response ISS
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISS
 biological_processGO:0034614 cellular response to reactive oxygen species ISS
 biological_processGO:0035426 extracellular matrix-cell signaling ISS
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IMP
 biological_processGO:0036119 response to platelet-derived growth factor ISS
 biological_processGO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase ISS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IBA
 biological_processGO:0038109 Kit signaling pathway ISS
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin ISS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway TAS
 biological_processGO:0050904 diapedesis ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049130 KITLG / P21583 / KIT ligand  / complex / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / reaction / complex






 

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