ENSG00000102010


Homo sapiens

Features
Gene ID: ENSG00000102010
  
Biological name :BMX
  
Synonyms : BMX / BMX non-receptor tyrosine kinase / P51813
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 15464246
Gene end: 15556529
  
Corresponding Affymetrix probe sets: 206464_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308774
Ensembl peptide - ENSP00000340082
Ensembl peptide - ENSP00000350224
NCBI entrez gene - 660     See in Manteia.
OMIM - 300101
RefSeq - XM_017029752
RefSeq - NM_001320866
RefSeq - NM_001721
RefSeq - NM_203281
RefSeq Peptide - NP_001712
RefSeq Peptide - NP_975010
RefSeq Peptide - NP_001307795
swissprot - P51813
Ensembl - ENSG00000102010
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BMXENSGALG00000016557Gallus gallus
 BmxENSMUSG00000031377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067148
TEC / P42680 / tec protein tyrosine kinaseENSG0000013560545
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326344
TXK / P42681 / TXK tyrosine kinaseENSG0000007496636
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700726
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332226
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251126
FER / P16591 / FER tyrosine kinaseENSG0000015142226
CSK / P41240 / C-terminal Src kinaseENSG0000010365323
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028840  Cytoplasmic tyrosine-protein kinase BMX
 IPR035875  BMX, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001865 NK T cell differentiation IBA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0097194 execution phase of apoptosis TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032587 ruffle membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000176783 RUFY1 / Q96T51 / RUN and FYVE domain containing 1  / reaction






 

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