ENSG00000135605


Homo sapiens

Features
Gene ID: ENSG00000135605
  
Biological name :TEC
  
Synonyms : P42680 / TEC / tec protein tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p11
Gene start: 48135783
Gene end: 48269864
  
Corresponding Affymetrix probe sets: 206301_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370912
Ensembl peptide - ENSP00000424567
Ensembl peptide - ENSP00000424365
NCBI entrez gene - 7006     See in Manteia.
OMIM - 600583
RefSeq - XM_011513737
RefSeq - XM_011513741
RefSeq - XM_017008569
RefSeq - NM_003215
RefSeq Peptide - NP_003206
swissprot - P42680
swissprot - D6RB05
swissprot - D6RB75
Ensembl - ENSG00000135605
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tecENSDARG00000098477Danio rerio
 TECENSGALG00000014124Gallus gallus
 TecENSMUSG00000029217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITK / Q08881 / IL2 inducible T cell kinaseENSG0000011326357
BTK / Q06187 / Bruton tyrosine kinaseENSG0000001067155
TXK / P42681 / TXK tyrosine kinaseENSG0000007496648
BMX / P51813 / BMX non-receptor tyrosine kinaseENSG0000010201048
ABL2 / P42684 / ABL proto-oncogene 2, non-receptor tyrosine kinaseENSG0000014332232
ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinaseENSG0000009700731
FES / P07332 / FES proto-oncogene, tyrosine kinaseENSG0000018251128
FER / P16591 / FER tyrosine kinaseENSG0000015142227
CSK / P41240 / C-terminal Src kinaseENSG0000010365326
MATK / P42679 / megakaryocyte-associated tyrosine kinaseENSG0000000726423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035572  Tyrosine-protein kinase Tec, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0010543 regulation of platelet activation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IMP
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding NAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
FCERI mediated Ca+2 mobilization
Interleukin-3, Interleukin-5 and GM-CSF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000113263 ITK / Q08881 / IL2 inducible T cell kinase  / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000135605 TEC / P42680 / tec protein tyrosine kinase  / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex






 

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