ENSMUSG00000029217


Mus musculus

Features
Gene ID: ENSMUSG00000029217
  
Biological name :Tec
  
Synonyms : Tec / tec protein tyrosine kinase
  
Possible biological names infered from orthology : P42680
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.2
Gene start: 72755716
Gene end: 72868483
  
Corresponding Affymetrix probe sets: 10530536 (MoGene1.0st)   1460204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123258
Ensembl peptide - ENSMUSP00000120155
Ensembl peptide - ENSMUSP00000123606
Ensembl peptide - ENSMUSP00000144458
Ensembl peptide - ENSMUSP00000071836
Ensembl peptide - ENSMUSP00000073509
Ensembl peptide - ENSMUSP00000109224
Ensembl peptide - ENSMUSP00000118980
NCBI entrez gene - 21682     See in Manteia.
MGI - MGI:98662
RefSeq - XM_011240719
RefSeq - NM_001113460
RefSeq - NM_001113461
RefSeq - NM_001113464
RefSeq - NM_013689
RefSeq - XM_006503845
RefSeq - XM_006503846
RefSeq - XM_006503847
RefSeq - XM_006503848
RefSeq - XM_011240718
RefSeq Peptide - NP_001106935
RefSeq Peptide - NP_038717
RefSeq Peptide - NP_001106931
RefSeq Peptide - NP_001106932
swissprot - A0A0J9YV29
swissprot - Q3U436
swissprot - Q8CFK4
swissprot - D6RJM5
swissprot - F6W1T9
swissprot - A0A0R4J1V5
Ensembl - ENSMUSG00000029217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tecENSDARG00000098477Danio rerio
 TECENSGALG00000014124Gallus gallus
 TECENSG00000135605Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039556
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126456
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137748
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489246
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659631
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684231
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012728
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315828
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231227
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035572  Tyrosine-protein kinase Tec, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0010543 regulation of platelet activation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
FCERI mediated Ca+2 mobilization
Interleukin-3, Interleukin-5 and GM-CSF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Pnpla6tm1Mos/Pnpla6tm1Mos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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