ENSMUSG00000026596


Mus musculus

Features
Gene ID: ENSMUSG00000026596
  
Biological name :Abl2
  
Synonyms : Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
  
Possible biological names infered from orthology : ABL proto-oncogene 2, non-receptor tyrosine kinase / P42684
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 156558786
Gene end: 156649568
  
Corresponding Affymetrix probe sets: 10350823 (MoGene1.0st)   1445483_at (Mouse Genome 430 2.0 Array)   1455495_at (Mouse Genome 430 2.0 Array)   1455682_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140125
Ensembl peptide - ENSMUSP00000027888
Ensembl peptide - ENSMUSP00000126181
Ensembl peptide - ENSMUSP00000133381
NCBI entrez gene - 11352     See in Manteia.
MGI - MGI:87860
RefSeq - XM_011238738
RefSeq - XM_006496616
RefSeq - XM_006496617
RefSeq - XM_006496620
RefSeq - XM_006496621
RefSeq - XM_006496622
RefSeq - XM_011238737
RefSeq - NM_001136104
RefSeq - NM_009595
RefSeq - XM_006496613
RefSeq - XM_006496614
RefSeq - XM_006496615
RefSeq Peptide - NP_033725
RefSeq Peptide - NP_001129576
swissprot - F8VQH0
swissprot - G3UWQ2
swissprot - B2RQ57
swissprot - A0A087WQB7
Ensembl - ENSMUSG00000026596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abl2ENSDARG00000013841Danio rerio
 ENSGALG00000030357Gallus gallus
 ABL2ENSG00000143322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684253
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126417
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921717
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039516
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231216
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137715
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315815
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489215
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493315
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035837  Tyrosine-protein kinase ABL, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010863 positive regulation of phospholipase C activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA


Pathways (from Reactome)
Pathway description
Role of ABL in ROBO-SLIT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Abl1tm2.2Goff/Abl1tm2.2Goff
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-Bc2/Tyrc-Bc2
Genetic Background: SELH/Bc

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0005357 retropulsion "when placed in a new environment, mice will walk backwards and then may walk forwards, whereas wild type mice will immediately walk forward, or freeze momentarily and then walk forward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0006098 absent cerebellar lobules "missing lobes of the cerebellum" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009216 abnormal peritoneum morphology "any structural abnormality of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009268 absent cerebellum fissure "absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S4/SvJae

 MP:0009978 abnormal cerebellum white matter morphology 
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0013551 decreased cerebellar granule cell precursor proliferation "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]
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Allelic Composition: Abl1tm2.1Goff/Abl1tm2.1Goff,Abl2tm1Ajk/Abl2tm1Ajk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / complex / reaction
 ENSMUSG00000031558 Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*  / reaction / complex






 

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