ENSDARG00000013841


Danio rerio

Features
Gene ID: ENSDARG00000013841
  
Biological name :abl2
  
Synonyms : abl2 / c-abl oncogene 2, non-receptor tyrosine kinase
  
Possible biological names infered from orthology : ABL proto-oncogene 2, non-receptor tyrosine kinase / P42684 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 14915332
Gene end: 14985276
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000041696
Ensembl peptide - ENSDARP00000140170
Ensembl peptide - ENSDARP00000117887
NCBI entrez gene - 570636     See in Manteia.
swissprot - B0UXN7
swissprot - B0UXN6
swissprot - A0A0R4IYB8
ZFIN ID - ZDB-GENE-020809-2
Ensembl - ENSDARG00000013841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000030357Gallus gallus
 ABL2ENSG00000143322Homo sapiens
 Abl2ENSMUSG00000026596Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSDARG0000003518749
csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *ENSDARG0000006799616
itk / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *ENSDARG0000001756516
fer / fer (fps/fes related) tyrosine kinase / P70451* / P16591* / FER tyrosine kinase* / Tyrosine-protein kinase Fer *ENSDARG0000001219616
btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *ENSDARG0000000443316
tec / tec protein tyrosine kinase / P42680*ENSDARG0000009847714
matk / megakaryocyte-associated tyrosine kinase / P42679*ENSDARG0000007467014
fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSDARG0000001144914
txk / TXK tyrosine kinase / P42681*ENSDARG000000150689


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015015  F-actin binding
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Role of ABL in ROBO-SLIT signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004246 slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*  / complex / reaction






 

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