ENSDARG00000017565


Danio rerio

Features
Gene ID: ENSDARG00000017565
  
Biological name :itk
  
Synonyms : IL2 inducible T cell kinase / itk
  
Possible biological names infered from orthology : Q03526 / Q08881 / Tyrosine-protein kinase ITK/TSK
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 34045284
Gene end: 34074510
  
Corresponding Affymetrix probe sets: Dr.596.1.S1_at (Zebrafish Array)   NM_131104_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022015
Ensembl peptide - ENSDARP00000142209
NCBI entrez gene - 798906     See in Manteia.
RefSeq - NM_131104
RefSeq Peptide - NP_571179
swissprot - F1R3M1
swissprot - A0A140LG31
ZFIN ID - ZDB-GENE-990415-261
Ensembl - ENSDARG00000017565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITKENSGALG00000003857Gallus gallus
 ITKENSG00000113263Homo sapiens
 ItkENSMUSG00000020395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
btk / Bruton agammaglobulinemia tyrosine kinase / P35991* / Q06187* / Bruton tyrosine kinase* / Tyrosine-protein kinase BTK *ENSDARG0000000443348
tec / tec protein tyrosine kinase / P42680*ENSDARG0000009847748
fer / fer (fps/fes related) tyrosine kinase / P70451* / P16591* / FER tyrosine kinase* / Tyrosine-protein kinase Fer *ENSDARG0000001219631
abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSDARG0000003518730
abl2 / c-abl oncogene 2, non-receptor tyrosine kinase / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSDARG0000001384129
fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSDARG0000001144928
csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *ENSDARG0000006799625
txk / TXK tyrosine kinase / P42681*ENSDARG0000001506824
matk / megakaryocyte-associated tyrosine kinase / P42679*ENSDARG0000007467023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001865 NK T cell differentiation IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000006468 grap2a / GRB2-related adaptor protein 2a / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / reaction / complex
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex
 ENSDARG00000038442 plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSDARG00000068763 plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex
 ENSDARG00000101169 grap2b / GRB2-related adaptor protein 2b / GRAP2* / O89100* / O75791* / GRB2-related adaptor protein 2*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr