ENSGALG00000003857


Gallus gallus

Features
Gene ID: ENSGALG00000003857
  
Biological name :ITK
  
Synonyms : IL2 inducible T cell kinase / ITK
  
Possible biological names infered from orthology : Q03526 / Q08881 / Tyrosine-protein kinase ITK/TSK
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 11417545
Gene end: 11445164
  
Corresponding Affymetrix probe sets: GgaAffx.2406.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006120
Ensembl peptide - ENSGALP00000056976
NCBI entrez gene - 416247     See in Manteia.
RefSeq - XM_414568
swissprot - A0A1D5PVK4
swissprot - E1C6Q5
Ensembl - ENSGALG00000003857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itkENSDARG00000017565Danio rerio
 ITKENSG00000113263Homo sapiens
 ItkENSMUSG00000020395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*ENSGALG0000001412459
BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *ENSGALG0000000495853
BMX / BMX non-receptor tyrosine kinase / P51813* / P97504* / Cytoplasmic tyrosine-protein kinase BMX *ENSGALG0000001655744
TXK / TXK tyrosine kinase / P42681* / P42682*ENSGALG0000001412743
ABL1 / ABL proto-oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / c-abl oncogene 1, non-receptor tyrosine kinase*ENSGALG0000000387529
ABL2* / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase* / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)*ENSGALG0000003035729
FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *ENSGALG0000000834027
CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*ENSGALG0000003127025
MATK / megakaryocyte-associated tyrosine kinase / P42679*ENSGALG0000000073623
FER / FER tyrosine kinase / P16591* / P70451* / Tyrosine-protein kinase Fer *ENSGALG0000000027314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0001865 NK T cell differentiation IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032633 interleukin-4 production IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / complex / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex






 

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