ENSMUSG00000020395


Mus musculus

Features
Gene ID: ENSMUSG00000020395
  
Biological name :Itk
  
Synonyms : Itk / Q03526 / Tyrosine-protein kinase ITK/TSK
  
Possible biological names infered from orthology : IL2 inducible T cell kinase / Q08881
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.1
Gene start: 46325150
Gene end: 46389515
  
Corresponding Affymetrix probe sets: 10385428 (MoGene1.0st)   1417171_at (Mouse Genome 430 2.0 Array)   1430833_at (Mouse Genome 430 2.0 Array)   1452518_a_at (Mouse Genome 430 2.0 Array)   1456836_at (Mouse Genome 430 2.0 Array)   1457120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020664
Ensembl peptide - ENSMUSP00000098864
Ensembl peptide - ENSMUSP00000104860
NCBI entrez gene - 16428     See in Manteia.
MGI - MGI:96621
RefSeq - NM_010583
RefSeq - NM_001281965
RefSeq - NM_001281966
RefSeq - NM_001281967
RefSeq - NM_001281968
RefSeq Peptide - NP_001268894
RefSeq Peptide - NP_001268895
RefSeq Peptide - NP_001268896
RefSeq Peptide - NP_001268897
RefSeq Peptide - NP_034713
swissprot - Q03526
swissprot - Q5STT7
swissprot - Q5STT8
Ensembl - ENSMUSG00000020395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itkENSDARG00000017565Danio rerio
 ITKENSGALG00000003857Gallus gallus
 ITKENSG00000113263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921756
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126452
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137748
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489244
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659629
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012729
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684229
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315828
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493324
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR001562  Zinc finger, Btk motif
 IPR001849  Pleckstrin homology domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035583  Tyrosine-protein kinase ITK, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001865 NK T cell differentiation IMP
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032609 interferon-gamma production IMP
 biological_processGO:0032633 interleukin-4 production IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpe65tm1Lrcb/Rpe65tm1Lrcb
Genetic Background: 129S6/SvEvTac-Rpe65tm1Lrcb

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Immp2lm1Btlr/Immp2lm1Btlr
Genetic Background: C57BL/6J-Immp2lm1Btlr

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln,Tg(tetO-Pou2af1)1Pjln/0,Tg(tTA)1Pjln/0
Genetic Background: involves: C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Vav1tm2Bbd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arid5btm1Whit/Arid5b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

Allelic Composition: H2b/H2b,Itktm1Ljb/Itktm1Ljb,Tg(TcrAND)53Hed/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

Allelic Composition: H2b/H2k,Itktm1Ljb/Itktm1Ljb,Tg(TcrAND)53Hed/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Arid5btm1Whit/Arid5b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Pou2af1tm1Pjln/Pou2af1tm1Pjln
Genetic Background: involves: C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itktm1Litt/Itktm1Litt,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Tg(Tcra2B4)1Mmd/?,Tg(Tcrb2B4)1Mmd/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

Allelic Composition: H2b/H2b,Itktm1Ljb/Itktm1Ljb,Tg(TcrAND)53Hed/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

Allelic Composition: H2b/H2k,Itktm1Ljb/Itktm1Ljb,Tg(TcrAND)53Hed/?
Genetic Background: involves: C3H/HeJ * C57BL/6 * C57BL/10

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6 * C57BL/10

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Itktm1Litt/Itktm1Litt,Vav1tm2Bbd/Vav1tm2Bbd
Genetic Background: B6.129-Itktm1Litt Vav1tm2Bbd

Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acox1tm1Jkr/Acox1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008343 abnormal gamma-delta T cell morphology "any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008353 increased mature gamma-delta T cell number "increased number of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

Allelic Composition: Itktm1Ljb/Itktm1Ljb,Txktm1Pls/Txktm1Pls
Genetic Background: B6.129-Txktm1Pls Itktm1Ljb

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: B6.129S4-Itktm1Litt

Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Itktm1Litt/Itktm1Litt
Genetic Background: B6.129-Itktm1Litt Cblbtm1Pngr

Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: involves: 129 * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb
Genetic Background: B10.129-Itktm1Ljb

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Itktm1Ljb/Itktm1Ljb,Rag1tm1Mom/Rag1tm1Mom,Tg(Tcra5CC7,Tcrb5CC7)IWep/?
Genetic Background: involves: 129 * C57BL/10

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

 MP:0011822 increased CD8-positive, alpha-beta memory T cell proliferation "increase in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division" [CL:0000909]
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Allelic Composition: Itkm1Btlr/Itkm1Btlr
Genetic Background: C57BL/6J-Itkm1Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Itkm2Btlr/Itkm2Btlr
Genetic Background: C57BL/6J-Itkm2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction






 

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