ENSMUSG00000000127


Mus musculus

Features
Gene ID: ENSMUSG00000000127
  
Biological name :Fer
  
Synonyms : Fer / P70451 / Tyrosine-protein kinase Fer
  
Possible biological names infered from orthology : FER tyrosine kinase / P16591
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.1
Gene start: 63896018
Gene end: 64139494
  
Corresponding Affymetrix probe sets: 10446351 (MoGene1.0st)   1421729_a_at (Mouse Genome 430 2.0 Array)   1426090_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000129
Ensembl peptide - ENSMUSP00000037418
NCBI entrez gene - 14158     See in Manteia.
MGI - MGI:105917
RefSeq - XM_017317244
RefSeq - NM_001037997
RefSeq - NM_001286415
RefSeq - NM_008000
RefSeq - XM_006523647
RefSeq - XM_011246293
RefSeq - XM_017317242
RefSeq - XM_017317243
RefSeq - XM_006523640
RefSeq - XM_006523641
RefSeq - XM_006523643
RefSeq - XM_006523645
RefSeq Peptide - NP_001273344
RefSeq Peptide - NP_032026
RefSeq Peptide - NP_001033086
swissprot - P70451
Ensembl - ENSMUSG00000000127
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ferENSDARG00000012196Danio rerio
 FERENSGALG00000000273Gallus gallus
 FERENSG00000151422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*ENSMUSG0000005315849
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039522
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659622
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126422
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684222
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921722
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137721
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493319
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489219
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR028539  Tyrosine-protein kinase Fer
 IPR031160  F-BAR domain
 IPR035849  Fes/Fps/Fer, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037452  Tyrosine-protein kinase Fer, F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0000278 mitotic cell cycle ISO
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010591 regulation of lamellipodium assembly ISS
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033007 negative regulation of mast cell activation involved in immune response IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0035426 extracellular matrix-cell signaling IMP
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus ISO
 biological_processGO:0036119 response to platelet-derived growth factor IDA
 biological_processGO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IMP
 biological_processGO:0038109 Kit signaling pathway IMP
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway ISO
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0050904 diapedesis IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway ISO
 cellular_componentGO:0000790 nuclear chromatin ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IPI
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbl1tm2Rmh/Nbl1tm2Rmh
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Fertm1Pag/Fertm1Pag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex






 

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