ENSMUSG00000053158


Mus musculus

Features
Gene ID: ENSMUSG00000053158
  
Biological name :Fes
  
Synonyms : Fes / P16879 / Tyrosine-protein kinase Fes/Fps
  
Possible biological names infered from orthology : FES proto-oncogene, tyrosine kinase / P07332
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80377756
Gene end: 80387946
  
Corresponding Affymetrix probe sets: 10564938 (MoGene1.0st)   1427368_x_at (Mouse Genome 430 2.0 Array)   1452410_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079733
Ensembl peptide - ENSMUSP00000146281
Ensembl peptide - ENSMUSP00000146078
Ensembl peptide - ENSMUSP00000146058
Ensembl peptide - ENSMUSP00000146041
Ensembl peptide - ENSMUSP00000145937
Ensembl peptide - ENSMUSP00000145917
Ensembl peptide - ENSMUSP00000145612
NCBI entrez gene - 14159     See in Manteia.
MGI - MGI:95514
RefSeq - NM_010194
RefSeq - XM_006540604
RefSeq Peptide - NP_034324
swissprot - A0A0U1RPD6
swissprot - A0A0U1RPB9
swissprot - A0A0U1RQ80
swissprot - P16879
swissprot - A0A0U1RNL3
swissprot - A0A0U1RPQ5
swissprot - A0A0U1RPN6
swissprot - A0A0U1RPM2
Ensembl - ENSMUSG00000053158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fesENSDARG00000011449Danio rerio
 FESENSGALG00000008340Gallus gallus
 FESENSG00000182511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fer / P70451 / Tyrosine-protein kinase Fer / P16591* / FER tyrosine kinase*ENSMUSG0000000012749
Bmx / P97504 / Cytoplasmic tyrosine-protein kinase BMX / P51813* / BMX non-receptor tyrosine kinase*ENSMUSG0000003137722
Tec / tec protein tyrosine kinase / P42680*ENSMUSG0000002921722
Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*ENSMUSG0000002039521
Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*ENSMUSG0000003126421
Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*ENSMUSG0000002684221
Abl2 / v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) / P42684* / ABL proto-oncogene 2, non-receptor tyrosine kinase*ENSMUSG0000002659621
Txk / P42682 / TXK tyrosine kinase / P42681*ENSMUSG0000005489220
Matk / megakaryocyte-associated tyrosine kinase / P42679*ENSMUSG0000000493320
Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*ENSMUSG0000003231218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001060  FCH domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016250  Tyrosine-protein kinase, Fes/Fps type
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027267  AH/BAR domain superfamily
 IPR031160  F-BAR domain
 IPR035849  Fes/Fps/Fer, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001578 microtubule bundle formation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006935 chemotaxis IBA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043304 regulation of mast cell degranulation IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:2000145 regulation of cell motility IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034987 immunoglobulin receptor binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Sema3A PAK dependent Axon repulsion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003749 down-turned corners of mouth "the lateral points of the oral cavity opening appear in a lower position that the rest of the lips" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Festm1Mcs/Festm1Mcs
Genetic Background: involves: 129X1/SvJ

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009432 increased fetal weight "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrpap1tm1Her/Lrpap1tm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Festm1Pag/Festm1Pag,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Festm1Mcs/Festm1Mcs
Genetic Background: involves: 129X1/SvJ

 MP:0030192 downturned snout "muzzle has a curve or tilt such that the tip points downwards" [MGI:anna]
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Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / complex / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex






 

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