ENSMUSG00000025810


Mus musculus

Features
Gene ID: ENSMUSG00000025810
  
Biological name :Nrp1
  
Synonyms : Neuropilin-1 / Nrp1 / P97333
  
Possible biological names infered from orthology : O14786
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 128358604
Gene end: 128503363
  
Corresponding Affymetrix probe sets: 10576639 (MoGene1.0st)   1418084_at (Mouse Genome 430 2.0 Array)   1448943_at (Mouse Genome 430 2.0 Array)   1448944_at (Mouse Genome 430 2.0 Array)   1457198_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026917
NCBI entrez gene - 18186     See in Manteia.
MGI - MGI:106206
RefSeq - XM_006530767
RefSeq - NM_008737
RefSeq - XM_006530766
RefSeq Peptide - NP_032763
swissprot - P97333
Ensembl - ENSMUSG00000025810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrp1aENSDARG00000102153Danio rerio
 NRP1ENSGALG00000007140Gallus gallus
 NRP1ENSG00000099250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG0000002596945
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657917
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119617
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG0000003448814
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG0000003510713
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG0000003060512
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198917
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG000000319367
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG000000312097
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312936
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG000000036176


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027146  Neuropilin-1
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021612 facial nerve structural organization IMP
 biological_processGO:0021636 trigeminal nerve morphogenesis IMP
 biological_processGO:0021637 trigeminal nerve structural organization IMP
 biological_processGO:0021649 vestibulocochlear nerve structural organization IMP
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IMP
 biological_processGO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030517 negative regulation of axon extension IGI
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035767 endothelial cell chemotaxis ISO
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0036486 ventral trunk neural crest cell migration IMP
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0038189 neuropilin signaling pathway IMP
 biological_processGO:0038190 VEGF-activated neuropilin signaling pathway IMP
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IDA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IMP
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IMP
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060385 axonogenesis involved in innervation IMP
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IMP
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis IMP
 biological_processGO:0060980 cell migration involved in coronary vasculogenesis IC
 biological_processGO:0060982 coronary artery morphogenesis IMP
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IMP
 biological_processGO:0061441 renal artery morphogenesis IMP
 biological_processGO:0061549 sympathetic ganglion development IMP
 biological_processGO:0061551 trigeminal ganglion development IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance IMP
 biological_processGO:0097374 sensory neuron axon guidance IMP
 biological_processGO:0097475 motor neuron migration IMP
 biological_processGO:0097490 sympathetic neuron projection extension IMP
 biological_processGO:0097491 sympathetic neuron projection guidance IMP
 biological_processGO:0150018 basal dendrite development IMP
 biological_processGO:0150020 basal dendrite arborization IGI
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IMP
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IMP
 biological_processGO:1902336 positive regulation of retinal ganglion cell axon guidance IMP
 biological_processGO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidance IMP
 biological_processGO:1902946 protein localization to early endosome IMP
 biological_processGO:1903375 facioacoustic ganglion development IMP
 biological_processGO:1904835 dorsal root ganglion morphogenesis IMP
 biological_processGO:1905040 otic placode development IMP
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005883 neurofilament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0097443 sorting endosome IDA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IMP
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IPI
 molecular_functionGO:0019838 growth factor binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0038085 vascular endothelial growth factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Plxna4tm1Hfu/Plxna4+
Genetic Background: B6.Cg-Plxna4tm1Hfu

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nrp1tm2.1Ddg/Nrp1tm2.1Ddg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: ApcMin/Apc+,Eregtm1Dwt/Eregtm1Dwt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nrp1tm2.1Ddg/Nrp1tm2.1Ddg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm2.1Ddg/Nrp1tm2.1Ddg
Genetic Background: involves: 129 * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Plxna1tm1Kik/Plxna1tm1Kik
Genetic Background: Not Specified

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxna1tm1Kik/Plxna1tm1Kik
Genetic Background: Not Specified

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Nrp1tm2Ddg/Nrp1tm2Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2Ddg,Olfr151tm28(cre)Mom/Olfr151tm28(cre)Mom,Tg(CAG-Bgeo/GFP)21Lbe/?
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0004159 double aortic arch "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: CD-1 * JF1

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0006356 abnormal third branchial arch artery morphology "any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009945 abnormal accessory olfactory bulb morphology "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mesp2tm13(cre/Esr1*)Ysa/Mesp2+
Genetic Background: involves: C57BL/6J

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nrp1tm2.1Ddg/Nrp1tm2.1Ddg
Genetic Background: involves: 129 * C57BL/6

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0010355 abnormal first branchial arch artery morphology "any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0010356 abnormal second branchial arch artery morphology "any structural anomaly of the vessels formed within the second pair of branchial arches in embryogenesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrp1tm1Ddg/Nrp1tm1Ddg,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nrp1tm1.1Izac/Nrp1tm1.1Izac
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu,Nrp2tm1Mkl/Nrp2+
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Nrp1tm1Hfu/Nrp1+,Nrp2tm1Mkl/Nrp2tm1Mkl
Genetic Background: involves: BALB/c * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / complex / reaction
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction / complex
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000056201 Cfl1 / P18760 / Cofilin-1 / P23528*  / complex / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000030077 Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*  / complex / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / reaction / complex






 

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