ENSMUSG00000031398


Mus musculus

Features
Gene ID: ENSMUSG00000031398
  
Biological name :Plxna3
  
Synonyms : P70208 / plexin A3 / Plxna3
  
Possible biological names infered from orthology : P51805
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 74329066
Gene end: 74344689
  
Corresponding Affymetrix probe sets: 10600419 (MoGene1.0st)   1420995_at (Mouse Genome 430 2.0 Array)   1420996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004326
NCBI entrez gene - 18846     See in Manteia.
MGI - MGI:107683
RefSeq - XM_006527903
RefSeq - NM_008883
RefSeq - XM_006527900
RefSeq - XM_006527901
RefSeq - XM_006527902
RefSeq Peptide - NP_032909
swissprot - P70208
swissprot - A0A158SIT4
Ensembl - ENSMUSG00000031398
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna3ENSDARG00000007172Danio rerio
 P51805ENSG00000130827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008466
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664060
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976560
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364635
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138533
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660631
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012329
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478521


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0021612 facial nerve structural organization IMP
 biological_processGO:0021637 trigeminal nerve structural organization IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IMP
 biological_processGO:0021860 pyramidal neuron development IMP
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IGI
 biological_processGO:0050919 negative chemotaxis IGI
 biological_processGO:0051495 positive regulation of cytoskeleton organization IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0097485 neuron projection guidance IMP
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IMP
 biological_processGO:1990138 neuron projection extension IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IMP


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mitfmi-Mhdabcc2/Mitfmi-Mhdabcc2
Genetic Background: C3HeB/FeJ-Mitfmi-Mhdabcc2/Ieg

Allelic Composition: Plxna3tm1Matl/Y
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex






 

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