ENSMUSG00000053646


Mus musculus

Features
Gene ID: ENSMUSG00000053646
  
Biological name :Plxnb1
  
Synonyms : plexin B1 / Plxnb1 / Q8CJH3
  
Possible biological names infered from orthology : O43157
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 109095389
Gene end: 109119917
  
Corresponding Affymetrix probe sets: 10589368 (MoGene1.0st)   1435254_at (Mouse Genome 430 2.0 Array)   1435255_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142431
Ensembl peptide - ENSMUSP00000071966
Ensembl peptide - ENSMUSP00000114358
Ensembl peptide - ENSMUSP00000115265
NCBI entrez gene - 235611     See in Manteia.
MGI - MGI:2154238
RefSeq - XM_006512081
RefSeq - XM_006512077
RefSeq - XM_006512078
RefSeq - XM_006512079
RefSeq - XM_006512080
RefSeq - NM_172775
RefSeq - XM_006512075
RefSeq - XM_006512076
RefSeq Peptide - NP_766363
swissprot - D3YUD0
swissprot - A0A0G2JDM9
swissprot - Q8CJH3
Ensembl - ENSMUSG00000053646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb1aENSDARG00000075821Danio rerio
 plxnb1bENSDARG00000017211Danio rerio
 PLXNB1ENSGALG00000006526Gallus gallus
 O43157ENSG00000164050Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138546
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660638
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008432
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139831
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664031
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012330
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976530
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0048675 axon extension IBA
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0050772 positive regulation of axonogenesis IGI
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IMP
 cellular_componentGO:0002116 semaphorin receptor complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IPI


Pathways (from Reactome)
Pathway description
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,KitW-v/KitW-v,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Plxnb1tm1Rkun/Plxnb1tm1Rkun
Genetic Background: Not Specified

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax8tm1.1(cre)Mbu/Pax8+,Plxnb1tm1Rkun/Plxnb1tm1Rkun,Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010981 abnormal branching involved in ureteric bud morphogenesis "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]
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Allelic Composition: Foxq1tm1Wen/Foxq1tm1Wen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Plxnb1tm1Rkun/Plxnb1tm1Rkun
Genetic Background: Not Specified

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Plxnb1tm1Rkun/Plxnb1tm1Rkun
Genetic Background: Not Specified

 MP:0011761 abnormal ureteric bud trunk morphology "any structural anomaly of the ureteric bud cells that elongate to form a rigid structure (stalk) consisting of polarized epithelial cells without branching; the stalks differentiate into the collecting system of the mature kidney, while the tip cells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into nephrons" [MGI:anna]
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Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / complex / reaction
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / reaction / complex
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex
 ENSMUSG00000059495 Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction
 ENSMUSG00000041977 Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*  / reaction / complex
 ENSMUSG00000058230 Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*  / complex / reaction






 

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