ENSMUSG00000058230


Mus musculus

Features
Gene ID: ENSMUSG00000058230
  
Biological name :Arhgap35
  
Synonyms : Arhgap35 / Q91YM2 / Rho GTPase activating protein 35
  
Possible biological names infered from orthology : Q9NRY4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 16493719
Gene end: 16614993
  
Corresponding Affymetrix probe sets: 10560282 (MoGene1.0st)   1434009_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075242
Ensembl peptide - ENSMUSP00000127379
NCBI entrez gene - 232906     See in Manteia.
MGI - MGI:1929494
RefSeq - XM_011250512
RefSeq - NM_172739
RefSeq - XM_006539809
RefSeq Peptide - NP_766327
swissprot - Q91YM2
swissprot - B2RTN5
Ensembl - ENSMUSG00000058230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap35aENSDARG00000062577Danio rerio
 arhgap35bENSDARG00000060297Danio rerio
 Q9NRY4ENSG00000160007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arhgap5 / Rho GTPase activating protein 5 / Q13017*ENSMUSG0000003513351
Arap2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 / Q8WZ64*ENSMUSG0000003799913
Arap3 / Q8R5G7 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 / Q8WWN8* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3*ENSMUSG0000002445112
Arap1 / Q4LDD4 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1*ENSMUSG0000003281212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001806  Small GTPase superfamily
 IPR002713  FF domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032835  Rho GTPase-activating protein, FF domain
 IPR036517  FF domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IMP
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0010976 positive regulation of neuron projection development IGI
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity IMP
 biological_processGO:0031668 cellular response to extracellular stimulus IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IGI
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043116 negative regulation of vascular permeability IMP
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0045724 positive regulation of cilium assembly IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0097485 neuron projection guidance IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Sema4D mediated inhibition of cell attachment and migration
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0000923 abnormal roof plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the dorsal midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0003604 single kidney 
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0003670 dilated glomerular capsule "an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0005549 retinal pigment epithelium hyperplasia "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

 MP:0011066 abnormal renal tubule epithelial cell primary cilium morphology "any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

Allelic Composition: Arhgap35tm1Jset/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Arhgap35m1Bchd/Arhgap35tm1Jset
Genetic Background: involves: 129S2/SvPas * C3H/HeNCrl * C57BL/6J

 MP:0012026 abnormal S-shaped body morphology "any structural anomaly of the successor of the comma-shaped body that contributes to the morphogenesis of the nephron" [GO:0072050]
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Allelic Composition: Arhgap35m1Bchd/Arhgap35m1Bchd
Genetic Background: involves: C3H/HeNCrl * C57BL/6J

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction / complex
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction / complex
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex / reaction






 

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External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr