ENSDARG00000062577


Danio rerio

Features
Gene ID: ENSDARG00000062577
  
Biological name :arhgap35a
  
Synonyms : arhgap35a / Rho GTPase activating protein 35a
  
Possible biological names infered from orthology : ARHGAP35 / Q91YM2 / Q9NRY4 / Rho GTPase activating protein 35
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 8604477
Gene end: 8763106
  
Corresponding Affymetrix probe sets: Dr.17714.1.S1_at (Zebrafish Array)   Dr.4800.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000085108
Ensembl peptide - ENSDARP00000127935
NCBI entrez gene - 100004299     See in Manteia.
RefSeq - XM_001343600
swissprot - E7F8G5
ZFIN ID - ZDB-GENE-120516-2
Ensembl - ENSDARG00000062577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9NRY4ENSG00000160007Homo sapiens
 Q91YM2ENSMUSG00000058230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgap35b / Rho GTPase activating protein 35b / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*ENSDARG0000006029776
arhgap5 / Rho GTPase activating protein 5 / Q13017*ENSDARG0000006129444
arap3 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 / Q8R5G7* / Q8WWN8* / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 *ENSDARG0000007680112
CR387919.1 / ARAP2* / Q8WZ64* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2*ENSDARG0000010051811
si:ch211-135f11.1 / ARAP1* / Q4LDD4* / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1* / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 *ENSDARG000000622218
FO704810.1ENSDARG000000874927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001806  Small GTPase superfamily
 IPR002713  FF domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032835  Rho GTPase-activating protein, FF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Sema4D mediated inhibition of cell attachment and migration
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035535 rasa1a / RAS p21 protein activator (GTPase activating protein) 1a / RASA1* / P20936* / RAS p21 protein activator 1*  / reaction / complex
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction / complex
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction / complex
 ENSDARG00000059956 ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex
 ENSDARG00000073665 rasa1b / RAS p21 protein activator (GTPase activating protein) 1b / RASA1* / P20936* / RAS p21 protein activator 1*  / reaction / complex
 ENSDARG00000017947 ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*  / reaction / complex






 

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