ENSDARG00000059956


Danio rerio

Features
Gene ID: ENSDARG00000059956
  
Biological name :ptk6b
  
Synonyms : ptk6b / PTK6 protein tyrosine kinase 6b
  
Possible biological names infered from orthology : protein tyrosine kinase 6 / PTK6 / PTK6 protein tyrosine kinase 6 / Q13882 / Q64434
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 17387325
Gene end: 17404011
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000078382
NCBI entrez gene - 767734     See in Manteia.
RefSeq - NM_001076672
RefSeq Peptide - NP_001070140
swissprot - Q08BY6
ZFIN ID - ZDB-GENE-060929-1150
Ensembl - ENSDARG00000059956
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTK6ENSG00000101213Homo sapiens
 Ptk6ENSMUSG00000038751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000001794750
SRMS / zgc:194282 / Q9H3Y6* / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites*ENSDARG0000007778341
frk / fyn-related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSDARG0000002780740
yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*ENSDARG0000000594139
blk / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSDARG0000000778338
fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000001137038
fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000002531938
yrk / Yes-related kinaseENSDARG0000000437838
hck / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSDARG0000005864737
lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSDARG0000010252537
lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*ENSDARG0000006791636
src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...ENSDARG0000000810736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1
ERBB2 Activates PTK6 Signaling
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
PTK6 Regulates Cell Cycle
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 Down-Regulation
PTK6 Activates STAT3
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction / complex
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction / complex
 ENSDARG00000069469 Q08BJ2 / khdrbs2 / KH domain containing, RNA binding, signal transduction associated 2 / Q9WU01* / Q5VWX1* / KH RNA binding domain containing, signal transduction associated 2* / KH domain-...  / reaction
 ENSDARG00000062577 arhgap35a / Rho GTPase activating protein 35a / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / reaction / complex
 ENSDARG00000060297 arhgap35b / Rho GTPase activating protein 35b / Q91YM2* / Q9NRY4* / ARHGAP35* / Rho GTPase activating protein 35*  / reaction / complex
 ENSDARG00000075121 hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...  / complex / reaction
 ENSDARG00000062688 gpnmb / glycoprotein (transmembrane) nmb / Q14956* / Q99P91* / glycoprotein nmb* / Transmembrane glycoprotein NMB *  / complex
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000092810 stap2a / signal transducing adaptor family member 2a / STAP2* / Q9UGK3* / Q8R0L1* / Signal-transducing adaptor protein 2 * / signal transducing adaptor family member 2*  / reaction / complex
 ENSDARG00000052856 khdrbs1a / KH domain containing, RNA binding, signal transduction associated 1a / Q07666* / Q60749* / KHDRBS1* / KH RNA binding domain containing, signal transduction associated 1* / KH dom...  / complex / reaction
 ENSDARG00000070475 khdrbs1b / KH domain containing, RNA binding, signal transduction associated 1b / Q07666* / Q60749* / KHDRBS1* / KH RNA binding domain containing, signal transduction associated 1* / KH dom...  / reaction / complex
 ENSDARG00000078108 dok1a / docking protein 1a / DOK1* / P97465* / Q99704* / docking protein 1*  / complex / reaction
 ENSDARG00000077783 SRMS / zgc:194282 / Q9H3Y6* / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites*  / reaction
 ENSDARG00000098112 btc / betacellulin, epidermal growth factor family member / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction






 

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