ENSDARG00000067916


Danio rerio

Features
Gene ID: ENSDARG00000067916
  
Biological name :lyn
  
Synonyms : lyn / LYN proto-oncogene, Src family tyrosine kinase
  
Possible biological names infered from orthology : P07948 / P25911
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 27577470
Gene end: 27609189
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000040554
NCBI entrez gene - 447804     See in Manteia.
RefSeq - NM_001004543
RefSeq Peptide - NP_001004543
swissprot - Q66I04
ZFIN ID - ZDB-GENE-040912-7
Ensembl - ENSDARG00000067916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LYNENSGALG00000042321Gallus gallus
 LYNENSG00000254087Homo sapiens
 LynENSMUSG00000042228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hck / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSDARG0000005864766
blk / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSDARG0000000778359
lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSDARG0000010252557
yrk / Yes-related kinaseENSDARG0000000437855
yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*ENSDARG0000000594155
fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000001137055
fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000002531954
src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...ENSDARG0000000810753
frk / fyn-related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSDARG0000002780745
ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000005995636
SRMS / zgc:194282 / Q9H3Y6* / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites*ENSDARG0000007778336
ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000001794734


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002431 Fc receptor mediated stimulatory signaling pathway IBA
 biological_processGO:0002513 tolerance induction to self antigen IBA
 biological_processGO:0002576 platelet degranulation IBA
 biological_processGO:0002902 regulation of B cell apoptotic process IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0030889 negative regulation of B cell proliferation IBA
 biological_processGO:0031175 neuron projection development IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0043304 regulation of mast cell degranulation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050855 regulation of B cell receptor signaling pathway IBA
 biological_processGO:0070667 negative regulation of mast cell proliferation IBA
 biological_processGO:0090022 regulation of neutrophil chemotaxis IMP
 biological_processGO:0090330 regulation of platelet aggregation IBA
 biological_processGO:0097028 dendritic cell differentiation IBA
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Signaling by SCF-KIT
Cell surface interactions at the vascular wall
FCGR activation
Fc epsilon receptor (FCERI) signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CD209 (DC-SIGN) signaling
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction / complex
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / complex
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex
 ENSDARG00000007671 ghrb / growth hormone receptor b / GHR* / P10912* / P16882* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / complex
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSDARG00000076179 ngef / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / complex
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / complex
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000103276 fcer1g / Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide / P20491* / P30273* / Fc fragment of IgE receptor Ig* / High affinity immunoglobulin epsilon receptor subunit gamma *  / complex






 

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